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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Edema and Nociception Induced by Philodryas patagoniensis Venom in Mice: A Pharmacological Evaluation with Implications for the Accident Treatment

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Author(s):
Lopes, Priscila Hess ; Rocha, Marisa M. T. ; Kuniyoshi, Alexandre Kazuo ; Vieira Portaro, Fernanda Calheta ; Goncalves, Luis Roberto C.
Total Authors: 5
Document type: Journal article
Source: Journal of Pharmacology and Experimental Therapeutics; v. 361, n. 3, p. 349-354, JUN 1 2017.
Web of Science Citations: 2
Abstract

We have investigated the mechanisms involved in the genesis of edema and nociception induced by Philodryas patagoniensis venom (PpV) injected into the footpad of mice. PpV induced dose-related edema and nociceptive effects. Pretreatment of mice with cyclooxygenase inhibitor (indomethacin), but not with cyclooxygenase 2 inhibitor (celecoxib) markedly inhibited both effects. Pretreatments with H-1 receptor antagonist (promethazine) or with dual histamine-serotonin inhibitor (cyproheptadine) failed in inhibiting both effects. In groups pretreated with captopril (angiotensin-converting enzyme inhibitor) the edema was unaltered, but nociception was clearly increased, suggesting the participation of kinins in the pathophysiology of the nociception but not of the edema-forming effect of PpV. When PpV was treated with EDTA, the nociception was similar to the one induced by untreated venom, but edema was markedly reduced. We concluded that PpV-induced edema and nociception have cyclooxygenase eicosanoids as the main mediators and no participation of vasoactive amines. Kinins seem to participate in nociception but not in edema induced by PpV. The results also suggest that metalloproteinases are the main compounds responsible for the edema, but not for the nociception induced by this venom. (AU)

FAPESP's process: 15/17053-5 - Study of inflamassomes activation, in human keratinocytes, by Loxosceles laeta spider venom and its sphingomyelinase D
Grantee:Priscila Hess Lopes
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/15344-7 - Efficacy of the bothropic antivenom from Butantan Institute: obtention, characterization and neutralization of serinepeptidases from the venom of Bothrops jararaca
Grantee:Alexandre Kazuo Kuniyoshi
Support Opportunities: Scholarships in Brazil - Doctorate