Lactone Derivatives Produced by a Phaeoacremonium sp., an Endophytic Fungus from Senna spectabilis

Author(s):Show less -

Silva, Gerald H. ; Zeraik, Maria L. ; de Oliveira, Camila M. ; Teles, Helder L. ; Trevisan, Henrique C. ; Pfenning, Ludwig H. ; Nicolli, Camila P. ; Young, Maria C. M. ; Mascarenhas, Yvonne P. ; Abreu, Lucas M. ; Saraiva, Amanda C. ; Medeiros, Alexandra I. ; Bolzani, Vanderlan da S. ; Araujo, Angela R.

• Document type: Journal article
• Source: Journal of Natural Products; v. 80, n. 5, p. 1674-1678, MAY 2017.
• Web of Science Citations: 6

Abstract

Three new isoaigialones, A, B, and C (1-3), along with aigialone (4), were isolated from the crude EtOAc extract of a Phaeoacremonium sp., an endophytic fungus obtained from the leaves of Senna spectabilis. The structures of these compounds were elucidated based on the analysis of spectroscopic data. Compounds 2 and 4 were active against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum. This is the first report of metabolites produced by an Phaeoacremonium sp., associated with S. spectabilis. (AU)

• FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 11/03017-6 - Natural products from plants of Cerrado and Atlantic Forest, potential models and useful for identifying prototypes with oxidizing action on neutrophils and myeloperoxidase (MPO) enzyme
• Grantee: Maria Luiza Zeraik
• Support Opportunities: Scholarships in Brazil - Post-Doctoral