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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Photobiomodulation therapy associated with treadmill training in the oxidative stress in a collagen-induced arthritis model

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Author(s):
dos Santos, Solange Almeida ; dos Santos Vieira, Marcia Ataize ; Brandao Simoes, Maira Cecilia ; Serra, Andrey Jorge ; Cesar Leal-Junior, Ernesto ; Camillo de Carvalho, Paulo de Tarso
Total Authors: 6
Document type: Journal article
Source: Lasers in Medical Science; v. 32, n. 5, p. 1071-1079, JUL 2017.
Web of Science Citations: 4
Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by chronic and systemic inflammation, which leads to the destruction of the cartilage and bone and affects tissues in multiple joints. Oxidative stress has been implicated with regards to involvement in various disease conditions, such as diabetes mellitus and neurodegenerative, respiratory, cardiovascular, and RA diseases. In vivo experimental studies using photobiomodulation therapy (PBMT) have shown positive effects in reducing lipid peroxidation and in increasing antioxidant activity. The regular practice of physical exercise has also been reported to be a beneficial treatment capable of reducing oxidative damage. Thus, the aim of this study was to analyze the effects of photobiomodulation therapy at 2- and 4-J doses associated with physical exercise on oxidative stress in an experimental model of RA in protein expression involving superoxide dismutase (SOD), glutathione peroxidase (GPX), and/or catalase (CAT) on thiobarbituric acid reactive substances (TBARS). In this study, 24 male Wistar rats divided into four groups were submitted to an RA model (i.e., collagen-induced arthritis, CIA), with the first immunization performed at the base of the tail on days 0 and 7 were included. After 28 days, a third intraarticular dose was administered in both knees of the animals. After the last induction, PBMT was started immediately, transcutaneously at two points (i.e., the medial and lateral), with a total of 15 applications. Treadmill exercise was also started the day after the last induction, and lasted for 5 weeks. With respect to results, we obtained the decreases in the lipid peroxidation and the increases of the antioxidant activities of SOD, GPX and CAT, with physical exercise associated to PBMT in doses of 2 and 4 J. In conclusion, physical exercise associated with PBMT decreases lipid peroxidation and increases antioxidant activity. (AU)

FAPESP's process: 15/13677-4 - EFFECTS OF LOW-LEVEL LASER THERAPY OF THE BIOAVAILABILITY STEM CELLS DERIVED FROM MESENCHYMAL ADIPOCYTES AND IMPLEMENTED ON KNEES WITH EXPERIMENTAL OSTEOARTHRITIS
Grantee:Paulo de Tarso Camillo de Carvalho
Support Opportunities: Regular Research Grants