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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biomass burning in the Amazon region causes DNA damage and cell death in human lung cells

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Author(s):
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Alves, Nilmara de Oliveira ; Vessoni, Alexandre Teixeira ; Quinet, Annabel ; Fortunato, Rodrigo Soares ; Kajitani, Gustavo Satoru ; Peixoto, Milena Simoes ; Hacon, Sandra de Souza ; Artaxo, Paulo ; Saldiva, Paulo ; Martins Menck, Carlos Frederico ; Batistuzzo de Medeiros, Silvia Regina
Total Authors: 11
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 7, SEP 7 2017.
Web of Science Citations: 9
Abstract

Most of the studies on air pollution focus on emissions from fossil fuel burning in urban centers. However, approximately half of the world's population is exposed to air pollution caused by biomass burning emissions. In the Brazilian Amazon population, over 10 million people are directly exposed to high levels of pollutants resulting from deforestation and agricultural fires. This work is the first study to present an integrated view of the effects of inhalable particles present in emissions of biomass burning. Exposing human lung cells to particulate matter smaller than 10 mu m (PM10), significantly increased the level of reactive oxygen species (ROS), inflammatory cytokines, autophagy, and DNA damage. Continued PM10 exposure activated apoptosis and necrosis. Interestingly, retene, a polycyclic aromatic hydrocarbon present in PM10, is a potential compound for the effects of PM10, causing DNA damage and cell death. The PM10 concentrations observed during Amazon biomass burning were sufficient to induce severe adverse effects in human lung cells. Our study provides new data that will help elucidate the mechanism of PM10-mediated lung cancer development. In addition, the results of this study support the establishment of new guidelines for human health protection in regions strongly impacted by biomass burning. (AU)

FAPESP's process: 14/02297-3 - Is the nucleotide excision repair pathway involved in the mechanism of action of urban air pollutants?
Grantee:Nilmara de Oliveira Alves Brito
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/15982-6 - Consequences of repair deficiencies in damaged genome
Grantee:Carlos Frederico Martins Menck
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/05014-0 - GoAmazon: interactions of the urban plume of Manaus with biogenic forest emissions in Amazonia
Grantee:Paulo Eduardo Artaxo Netto
Support type: Research Program on Global Climate Change - Thematic Grants