| Full text | |
| Author(s): |
-Felice, Franco Della
;
Sarotti, Ariel M.
;
Pilli, Ronaldo A.
Total Authors: 3
|
| Document type: | Journal article |
| Source: | Journal of Organic Chemistry; v. 82, n. 17, p. 9191-9197, SEP 1 2017. |
| Web of Science Citations: | 8 |
| Abstract | |
The total synthesis and structural revision of (+)-cryptoconcatone H are described. Guided by computational studies for the final structure assignment, the stereogenic centers at the tetrahydropyran moiety of (+)-cryptoconcatone H were assembled through catalytic asymmetric methodologies: Krische allylation, cross-metathesis reaction, and THP formation via Pd(II)-catalyzed cyclization. Finally, a Krische allylation reaction established the last stereocenter, and the lactone moiety was formed by ring-closing metathesis. (AU) | |
| FAPESP's process: | 14/25474-8 - Synthesis and biological evualuation of Brevipolide A, Cryptomoskatone F1 and related compounds |
| Grantee: | Franco Della Felice |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 16/12541-4 - A biomimetic approach to the total synthesis of Stemona alkaloids |
| Grantee: | Ronaldo Aloise Pilli |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/07607-8 - OCRC - Obesity and Comorbidities Research Center |
| Grantee: | Licio Augusto Velloso |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |