IncX3 plasmid harboring a non-Tn4401 genetic element (NTEKPC) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258

Author(s)

Cerdeira, Louise T. ^[1] ; Cunha, Marcos P. V. ^[2] ; Francisco, Gabriela R. ^[3] ; Bueno, Maria Fernanda C. ^[3] ; Araujo, Bruna F. ^[4] ; Ribas, Rosineide M. ^[4] ; Gontijo-Filho, Paulo P. ^[4] ; Knobl, Terezinha ^[2] ; Garcia, Doroti de Oliveira ^[3] ; Lincopan, Nilton ^{[5, 1]}

Affiliation

^[1] Univ Sao Paulo, Sch Pharm, Dept Clin Anal, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Vet Med, Sao Paulo - Brazil

^[3] Adolfo Lutz Inst, Ctr Bacteriol, Sao Paulo - Brazil

^[4] Univ Fed Uberlandia, Inst Biomed Sci, Uberlandia, MG - Brazil

^[5] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil

• Document type: Journal article
• Source: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE; v. 89, n. 2, p. 164-167, OCT 2017.
• Web of Science Citations: 7

Abstract

IncX-type plasmids have achieved clinical significance for their contribution in the dissemination of genes confering resistance to carbapenems (most bla(KPC)- and bla(NDM)-type genes) and polymyxins (mcr-type genes), both antibiotics considered last resort for multidrug-resistant Gram-negative infections. In this study, we report the identification and complete sequence analysis of an IncX3 plasmid (designated pKP1194a) carrying a non-Tn4401 genetic element (NTEKPC) of tnpR-tnpA (partial)-bla(KPC-2)-Delta ISKpn6/traN, originating from a hospital-associated lineage of K. pneumoniae belonging to the ST340/CG258, with epidemiological link to Brazil. (C) 2017 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 16/08593-9 - Pan-Resistome of beta-lactamase (KPC-2, CTX-M-8, CTX-M-15)-producing Klebsiella pneumoniae and Escherichia coli isolates endemic in Brazil
• Grantee: Nilton Erbet Lincopan Huenuman
• Support Opportunities: Regular Research Grants