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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biomolecular corona formation: nature and bactericidal impact on surface-modified silica nanoparticles

Full text
Author(s):
Emer, Maiara [1] ; Cardoso, Mateus Borba [1]
Total Authors: 2
Affiliation:
[1] LNLS, CNPEM, Lab Nacl Nanotecnol LNNano, Caixa Postal 6192, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF MATERIALS CHEMISTRY B; v. 5, n. 40, p. 8052-8059, OCT 28 2017.
Web of Science Citations: 5
Abstract

Biological fluids contain a plethora of different components that can coat nanoparticle's surface and critically affect their interaction with living systems. The recent literature has focused efforts on understanding the overall protein role in this nanoparticle's coating (commonly called a protein corona) without considering other components' influence. Here, we report a protocol to study the relationship between biological fluid components excluding proteins (referred to as a biomolecular corona) and nanoparticles. For this purpose, functionalized silica nanoparticles were duly synthesized to experimentally investigate the extent of biomolecular corona adsorption over different surfaces. This adsorption was directly correlated with the silica surface chemical constitution, while the extent of biomolecular corona coating affected the overall surface charge and the colloidal stability of the functionalized nanoparticles. In addition, the bactericidal properties of biomolecular corona-coated nanoparticles were tested against two medically relevant bacteria (Escherichia coli and Staphylococcus aureus). Biological results indicated that the presence and the extent of the biomolecular corona affect the bactericidal properties of the nanoparticles. (AU)

FAPESP's process: 14/01241-4 - Nanoparticle-bacteria interaction study based on surface functionalization of nanometric structures
Grantee:Maiara Emer
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 14/22322-2 - Functionalization of silica nanoparticles: increasing biological interaction
Grantee:Mateus Borba Cardoso
Support Opportunities: Regular Research Grants
FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
Grantee:Watson Loh
Support Opportunities: Research Projects - Thematic Grants