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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Statistical Framework to Interpret Individual Response to Intervention : Paving the Way for Personalized Nutrition and Exercise Prescription

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Author(s):
Swinton, Paul A. [1] ; Hemingway, Ben Stephens [1] ; Saunders, Bryan [2, 3] ; Gualano, Bruno [2] ; Dolan, Eimear [2]
Total Authors: 5
Affiliation:
[1] Robert Gordon Univ, Sch Hlth Sci, Aberdeen - Scotland
[2] Univ Sao Paulo, Fac Med, Appl Physiol & Nutr Res Grp, Rheumatol Div, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Inst Orthopaed & Traumotol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: FRONTIERS IN NUTRITION; v. 5, MAY 28 2018.
Web of Science Citations: 16
Abstract

The concept of personalized nutrition and exercise prescription represents a topical and exciting progression for the discipline given the large inter-individual variability that exists in response to virtually all performance and health related interventions. Appropriate interpretation of intervention-based data from an individual or group of individuals requires practitioners and researchers to consider a range of concepts including the confounding influence of measurement error and biological variability. In addition, the means to quantify likely statistical and practical improvements are facilitated by concepts such as confidence intervals (CIs) and smallest worthwhile change (SWC). The purpose of this review is to provide accessible and applicable recommendations for practitioners and researchers that interpret, and report personalized data. To achieve this, the review is structured in three sections that progressively develop a statistical framework. Section 1 explores fundamental concepts related to measurement error and describes how typical error and CIs can be used to express uncertainty in baseline measurements. Section 2 builds upon these concepts and demonstrates how CIs can be combined with the concept of SWC to assess whether meaningful improvements occur post-intervention. Finally, section 3 introduces the concept of biological variability and discusses the subsequent challenges in identifying individual response and non-response to an intervention. Worked numerical examples and interactive Supplementary Material are incorporated to solidify concepts and assist with implementation in practice. (AU)

FAPESP's process: 13/14746-4 - Carnosine metabolism in skeletal muscle: a multi-approach study
Grantee:Bruno Gualano
Support type: Research Projects - Thematic Grants
FAPESP's process: 17/09635-0 - Factors determining the carnosine content of human skeletal muscle: influence of age and sex
Grantee:Eimear Bernadette Dolan
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/11328-2 - Carnosine metabolism in skeletal muscle: a multi-approach study. Substudy 3: exploring carnosine role in skeletal muscle
Grantee:Eimear Bernadette Dolan
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 17/04973-4 - Nutritional supplementation and exercise to optimise exercise performance: focus on individual responses and a step towards personalized sports nutrition
Grantee:Bryan Saunders
Support type: Scholarships in Brazil - Young Researchers