Solution-combustion synthesis of doped TiO2 compounds and its potential antileishmanial activity mediated by photodynamic therapy

Author(s)

Lopera, A. A. ^{[1, 2]} ; Velasquez, A. M. A. ^{[3, 1]} ; Clementino, L. C. ^{[3, 1]} ; Robledo, S. ^[4] ; Montoya, A. ^[4] ; de Freitas, L. M. ^[1] ; Bezzon, V. D. N. ^[5] ; Fontana, C. R. ^[1] ; Garcia, C. ^[2] ; Graminha, M. A. S. ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara - Brazil

^[2] Univ Nacl Colombia, Sede Medellin, Grp Ceram & Vitreos, Bogota - Colombia

^[3] Sao Paulo State Univ UNESP, Inst Chem, Araraquara - Brazil

^[4] Univ Antioquia, PECET Inst Invest Med, Fac Med, Medellin - Colombia

^[5] Univ Sao Paulo, Dept Pharm, Fac Pharmaceut Sci, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY; v. 183, p. 64-74, JUN 2018.
• Web of Science Citations: 4

Abstract

Photodynamic therapy has emerged as an altemative treatment for cutaneous leishmaniasis, and compounds with photocatalytic behavior are promising candidates to develop new therapeutic strategies for the treatment of this parasitic disease. Titanium dioxide TiO2 is a semiconductor ceramic material that shows excellent photo catalytic and antimicrobial activity under Ultraviolet irradiation. Due to the harmful effects of UV radiation, many efforts have been made in order to enhance both photocatalytic and antimicrobial properties of TiO2 in the visible region of the spectrum by doping or through modifications in the route of synthesis. Herein, Fe-, Zn-, or Pt-doped TiO2 nanostructures were synthesized by solution-combustion route. The obtained compounds presented aggregates of 100 nm, formed by particles smaller than 20 nm. Doping compounds shift the absorption spectrum towards the visible region, allowing production of reactive oxygen species in the presence of oxygen and molecular water when the system is irradiated in the visible spectrum. The Pt (EC50 = 18.2 +/- 0.8 mu g/mL) and Zn (EC50 = 16.4 +/- 0.3 mu g/mL) doped TiO2 presented the higher antileishmanial activities under visible irradiation and their application as photosensitizers in photodynamic therapy (PDT) strategies for the treatment of cutaneous leishmaniasis should be considered. (AU)

• FAPESP's process: 17/03552-5 - Leishmaniasis: from screening to the study of mechanisms of action, a contribution to the discovery of new bioactive molecules
• Grantee: Marcia Aparecida Silva Graminha
• Support type: Regular Research Grants
• FAPESP's process: 16/05345-4 - Improving antimicrobial photodynamic therapy for infectious disease associating peptide aurein 1.2
• Grantee: Carla Raquel Fontana Mendonça
• Support type: Regular Research Grants
• FAPESP's process: 16/19289-9 - Characterization of Mechanism of cell death potentially induced by a binuclear antileishmanial cyclopalladated CP2: a contribution to the rational drug development
• Grantee: Angela Maria Arenas Velásquez
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 13/08248-1 - Leishmaniasis and bioinorganic compounds containing Au(I) and Pd(II): antileishmanial activities, mechanims of action and putative new drug targets
• Grantee: Marcia Aparecida Silva Graminha
• Support type: Regular Research Grants
• FAPESP's process: 14/24581-5 - Evaluation of the role of photodynamic therapy combined with antimicrobial peptides against bacterial resistance
• Grantee: Laura Marise de Freitas
• Support type: Scholarships in Brazil - Doctorate