Treatment of periodontitis in smokers with multiple sessions of antimicrobial photodynamic therapy or systemic antibiotics: A randomized clinical trial

Author(s)

Theodoro, Leticia Helena ^{[1, 2]} ; Assem, Naida Zanini ^{[1, 2]} ; Longo, Mariellen ^{[1, 2]} ; Ferro Alves, Marcio Luiz ^{[1, 2]} ; Duque, Cristiane ^[3] ; Stipp, Rafael Nobrega ^[4] ; Vizoto, Natalia Leal ^[4] ; Garcia, Valdir Gouveia ^{[1, 2]}

Affiliation

^[1] Sao Paulo State Univ UNESP, Dept Surg, Dent Sch Aracatuba, Sao Paulo - Brazil

^[2] Sao Paulo State Univ UNESP, Integrated Clin, Dent Sch Aracatuba, Sao Paulo - Brazil

^[3] Sao Paulo State Univ UNESP, Dept Pediat & Social Dent, Dent Sch Aracatuba, Sao Paulo - Brazil

^[4] Univ Estadual Campinas, Dept Oral Diag, Dent Sch Piracicaba, Campinas, SP - Brazil

• Document type: Journal article
• Source: Photodiagnosis and Photodynamic Therapy; v. 22, p. 217-222, JUN 2018.
• Web of Science Citations: 8

Abstract

Background: The aim of this study was to evaluate the effects of non-surgical periodontal therapies on smokers with chronic periodontitis, involving multiple adjunctive applications of antimicrobial photodynamic therapy (aPDT), and systemic metronidazole (MTZ) with amoxicillin (AMX). Methods: All participants were treated with scaling and root planing (SRP). Seventeen patients received 400 mg of MTZ and 500 mg of AMX three times per day for 7 days (MTZ + AMX). Additionally, 17 patients received a placebo, and 17 patients were treated with three applications of aPDT (immediately, 48 h and 96 h after SRP). Clinical and microbiological examinations were performed at baseline and at 90 and 180 days post-therapy. Subgingival samples were analyzed using real-time polymerase chain reaction. Results: After 180 days, the patients in groups MTZ + AMX and aPDT had significantly lower mean probing depths, more clinical attachment level gains and less bleeding on probing. At 180 days, in the moderate pocket there was a reduction in the levels of Porphyromonas gingivalis and Prevotella nigrescens in the MTZ + AMX group, while group aPDT showed a reduction in Prevotella nigrescens. Furthermore, at 180 days, in the deep pocket a reduction in Porphyromonas gingivalis, Prevotella intermedia and Prevotella nigrescens was observed in group MTZ + AMX, as well as a reduction in the levels of Prevotella intermedia and Prevotella nigrescens in group aPDT. Conclusion: In smokers with periodontitis, the MTZ + AMX and aPDT treatments significantly improved the effects of SRP. (AU)

• FAPESP's process: 13/05424-3 - Clinical and microbiological effects of aPDT compared with systemic amoxicillin/ metronidazole in the treatment of chronic periodontitis in smokers: a randomized controlled study
• Grantee: Naida Zanini Assem
• Support Opportunities: Scholarships in Brazil - Master