| Full text | |
| Author(s): |
Theodoro, Leticia Helena
[1, 2]
;
Assem, Naida Zanini
[1, 2]
;
Longo, Mariellen
[1, 2]
;
Ferro Alves, Marcio Luiz
[1, 2]
;
Duque, Cristiane
[3]
;
Stipp, Rafael Nobrega
[4]
;
Vizoto, Natalia Leal
[4]
;
Garcia, Valdir Gouveia
[1, 2]
Total Authors: 8
|
| Affiliation: | [1] Sao Paulo State Univ UNESP, Dept Surg, Dent Sch Aracatuba, Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Integrated Clin, Dent Sch Aracatuba, Sao Paulo - Brazil
[3] Sao Paulo State Univ UNESP, Dept Pediat & Social Dent, Dent Sch Aracatuba, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Dept Oral Diag, Dent Sch Piracicaba, Campinas, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Photodiagnosis and Photodynamic Therapy; v. 22, p. 217-222, JUN 2018. |
| Web of Science Citations: | 8 |
| Abstract | |
Background: The aim of this study was to evaluate the effects of non-surgical periodontal therapies on smokers with chronic periodontitis, involving multiple adjunctive applications of antimicrobial photodynamic therapy (aPDT), and systemic metronidazole (MTZ) with amoxicillin (AMX). Methods: All participants were treated with scaling and root planing (SRP). Seventeen patients received 400 mg of MTZ and 500 mg of AMX three times per day for 7 days (MTZ + AMX). Additionally, 17 patients received a placebo, and 17 patients were treated with three applications of aPDT (immediately, 48 h and 96 h after SRP). Clinical and microbiological examinations were performed at baseline and at 90 and 180 days post-therapy. Subgingival samples were analyzed using real-time polymerase chain reaction. Results: After 180 days, the patients in groups MTZ + AMX and aPDT had significantly lower mean probing depths, more clinical attachment level gains and less bleeding on probing. At 180 days, in the moderate pocket there was a reduction in the levels of Porphyromonas gingivalis and Prevotella nigrescens in the MTZ + AMX group, while group aPDT showed a reduction in Prevotella nigrescens. Furthermore, at 180 days, in the deep pocket a reduction in Porphyromonas gingivalis, Prevotella intermedia and Prevotella nigrescens was observed in group MTZ + AMX, as well as a reduction in the levels of Prevotella intermedia and Prevotella nigrescens in group aPDT. Conclusion: In smokers with periodontitis, the MTZ + AMX and aPDT treatments significantly improved the effects of SRP. (AU) | |
| FAPESP's process: | 13/05424-3 - Clinical and microbiological effects of aPDT compared with systemic amoxicillin/ metronidazole in the treatment of chronic periodontitis in smokers: a randomized controlled study |
| Grantee: | Naida Zanini Assem |
| Support Opportunities: | Scholarships in Brazil - Master |