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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Treatment of periodontitis in smokers with multiple sessions of antimicrobial photodynamic therapy or systemic antibiotics: A randomized clinical trial

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Theodoro, Leticia Helena [1, 2] ; Assem, Naida Zanini [1, 2] ; Longo, Mariellen [1, 2] ; Ferro Alves, Marcio Luiz [1, 2] ; Duque, Cristiane [3] ; Stipp, Rafael Nobrega [4] ; Vizoto, Natalia Leal [4] ; Garcia, Valdir Gouveia [1, 2]
Total Authors: 8
[1] Sao Paulo State Univ UNESP, Dept Surg, Dent Sch Aracatuba, Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Integrated Clin, Dent Sch Aracatuba, Sao Paulo - Brazil
[3] Sao Paulo State Univ UNESP, Dept Pediat & Social Dent, Dent Sch Aracatuba, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Dept Oral Diag, Dent Sch Piracicaba, Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Photodiagnosis and Photodynamic Therapy; v. 22, p. 217-222, JUN 2018.
Web of Science Citations: 8

Background: The aim of this study was to evaluate the effects of non-surgical periodontal therapies on smokers with chronic periodontitis, involving multiple adjunctive applications of antimicrobial photodynamic therapy (aPDT), and systemic metronidazole (MTZ) with amoxicillin (AMX). Methods: All participants were treated with scaling and root planing (SRP). Seventeen patients received 400 mg of MTZ and 500 mg of AMX three times per day for 7 days (MTZ + AMX). Additionally, 17 patients received a placebo, and 17 patients were treated with three applications of aPDT (immediately, 48 h and 96 h after SRP). Clinical and microbiological examinations were performed at baseline and at 90 and 180 days post-therapy. Subgingival samples were analyzed using real-time polymerase chain reaction. Results: After 180 days, the patients in groups MTZ + AMX and aPDT had significantly lower mean probing depths, more clinical attachment level gains and less bleeding on probing. At 180 days, in the moderate pocket there was a reduction in the levels of Porphyromonas gingivalis and Prevotella nigrescens in the MTZ + AMX group, while group aPDT showed a reduction in Prevotella nigrescens. Furthermore, at 180 days, in the deep pocket a reduction in Porphyromonas gingivalis, Prevotella intermedia and Prevotella nigrescens was observed in group MTZ + AMX, as well as a reduction in the levels of Prevotella intermedia and Prevotella nigrescens in group aPDT. Conclusion: In smokers with periodontitis, the MTZ + AMX and aPDT treatments significantly improved the effects of SRP. (AU)

FAPESP's process: 13/05424-3 - Clinical and microbiological effects of aPDT compared with systemic amoxicillin/ metronidazole in the treatment of chronic periodontitis in smokers: a randomized controlled study
Grantee:Naida Zanini Assem
Support type: Scholarships in Brazil - Master