An electrochemical furosemide sensor based on pencil graphite surface modified with polymer film Ni-salen and Ni(OH)(2)/C nanoparticles

Author(s)

Martins, Thiago S. ^[1] ; Bott-Neto, Jose L. ^[1] ; Raymundo-Pereira, Paulo A. ^[2] ; Ticianelli, Edson A. ^[1] ; Machado, Sergio A. S. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sao Carlos Inst Chem, Ave Trabalhador Sao Carlense 400, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Sao Paulo, Sao Carlos Inst Phys, Ave Trabalhador Sao Carlense 400, BR-13560970 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: SENSORS AND ACTUATORS B-CHEMICAL; v. 276, p. 378-387, DEC 10 2018.
• Web of Science Citations: 3

Abstract

In this work, an advanced electrochemical sensor based on pencil graphite electrode modified via electropolymerization of the N,N'-bis(salicylidene) ethylenediaminonickel(II) monomer in the presence of carbon supported Ni(OH)(2) nanoparticles(here called as poly{[}Ni(salen)] and Ni(OH)(2)/C) was developed and investigated for furosemide(FUR) quantification in alkaline medium. The electrochemical sensor and its components were extensively characterized by physico-chemical techniques, while the furosemide oxidation process was investigated by in situ Fourier transform infrared spectroscopy(in situ FTIR). These results indicate that the oxidation of furosemide leads to the formation of 2-amino-4-chloro-5-sulfamoylbenzoate and 5-hydroxy-furan-2-carboxylate in these conditions. The electrochemical response of the modified graphite electrode(MGE) for the determination of FUR was measured by cyclic voltammetry(CV). The calibration curve(change of voltammetric peak current vs. FUR concentration) presented a linear range from 2.5 x 10(-10) M to 2.7 x 10(-9) M with a calculated limit of detection as low as 1.4 x 10(-10) M under the optimized conditions, which is lower than values reported in the literature. The ultra-low sensitivity obtained with the MGE sensor was attributed to an additiveeffect involving the poly{[}Ni(salen)] film and the high surface carbon-supported Ni(OH)(2) nanoparticles. (AU)

• FAPESP's process: 16/01919-6 - Design and fabrication of nanostructured flexible devices for biomarkers detection
• Grantee: Paulo Augusto Raymundo Pereira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/12759-0 - Development of an advanced electroanalytical methodology for quantification of the hormones 17²-estradiol and 17±-etinilestradiol in supply water samples using electrodes modified with graphene, gold nanoparticles and quantum dots
• Grantee: Sergio Antonio Spinola Machado
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/16930-7 - Electrocatalysis V: electrocatalytic processes of chemical and electrical energy interconversion
• Grantee: Edson Antonio Ticianelli
• Support Opportunities: Research Projects - Thematic Grants