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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Specificity of peptidases secreted by filamentous fungi

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Author(s):
Abou Hamin Neto, Youssef Ali [1] ; da Rosa Garzon, Nathalia Gonsales [1] ; Pedezzi, Rafael [1] ; Cabral, Hamilton [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Cafe Ave S-N, BR-14040903 Ribeirao Preto - Brazil
Total Affiliations: 1
Document type: Journal article
Source: BIOENGINEERED; v. 9, n. 1, p. 30-37, 2018.
Web of Science Citations: 3
Abstract

Peptidases are enzymes that cleave peptide bonds, yielding proteins and peptides. Enzymes in this class also perform several other functions, regulating the activation or inactivation of target substrates via proteolysis. Owing to these functions, peptidases have been extensively used in industrial and biotechnological applications. Given their potential functions, it is important to optimize the use of these enzymes, which requires determination of the specificity of each peptidase. The peptidase specificity must be taken into account in choosing a peptidase to catalyze the available protein source within the desired application. The specificity of a peptidase defines the profile of enzyme-substrate interactions, and for this the catalytic site and the arrangement of the amino acid residues involved in peptide bond cleavage need to be known. The catalytic sites of peptidases may be composed of several subsites that interact with amino acid residues for proteolysis. Filamentous fungi produce peptidases with varying specificity, and here we provide a review of those reported to date and their potential applications. (AU)

FAPESP's process: 11/06986-0 - Determination of the specificity of peptidases isolated from fungi using fluorescence resonance energy transfer (FRET) peptides as substrates
Grantee:Hamilton Cabral
Support Opportunities: Regular Research Grants
FAPESP's process: 12/18278-2 - Bioprocess, purification and characterization of peptidases produced by fungi Eupenicillium javanicum and Myceliophthora sp. and evaluating the production of biologically active peptides
Grantee:Youssef Ali Abou Hamin Neto
Support Opportunities: Scholarships in Brazil - Doctorate