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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium

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Leoncini, Emanuele [1] ; Vukovic, Vladimir [1] ; Cadoni, Gabriella [2] ; Giraldi, Luca [1] ; Pastorino, Roberta [1] ; Arzani, Dario [1] ; Petrelli, Livia [2] ; Wunsch-Filho, Victor [3] ; Toporcov, Tatiana Natasha [3] ; Moyses, Raquel Ayub [4] ; Matsuo, Keitaro [5] ; Bosetti, Cristina [6] ; La Vecchia, Carlo [7] ; Serraino, Diego [8] ; Simonato, Lorenzo [9] ; Merletti, Franco [10] ; Boffetta, Paolo [11, 12] ; Hashibe, Mia [13, 14] ; Lee, Yuan-Chin Amy [13] ; Boccia, Stefania [15]
Total Authors: 20
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[1] Univ Cattolica Sacro Cuore, Inst Publ Hlth, Sect Hyg, Rome - Italy
[2] Univ Cattolica Sacro Cuore, Inst Otorhinolaryngol, Rome - Italy
[3] Univ Sao Paulo, Fac Saude Publ, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Cirurgia Cabeca & Pescoco LIM 28, Sao Paulo - Brazil
[5] Aichi Canc Ctr, Res Inst, Nagoya, Aichi - Japan
[6] IRCCS Ist Ric Farmacol Mario Negri, Dept Oncol, Milan - Italy
[7] Univ Milan, Dept Clin Sci & Community Hlth, Milan - Italy
[8] IRCCS Ctr Riferimento Oncol, SOC Epidemiol & Biostat, Aviano - Italy
[9] Dept Mol Med, Lab Publ Hlth & Populat Studies, Padua - Italy
[10] Univ Turin, Dept Med Sci, Turin - Italy
[11] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 - USA
[12] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 - USA
[13] Univ Utah, Sch Med, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT 84112 - USA
[14] Univ Utah, Sch Med, Huntsman Canc Inst, Salt Lake City, UT - USA
[15] Univ Cattolica Sacro Cuore, Fdn Policlin Agostino Gemelli IRCCS, Inst Publ Hlth, Sect Hyg, Largo F Vito 1, I-00168 Rome - Italy
Total Affiliations: 15
Document type: Journal article
Source: EUROPEAN JOURNAL OF EPIDEMIOLOGY; v. 33, n. 12, p. 1205-1218, DEC 2018.
Web of Science Citations: 4

Recurrence and second primary cancer (SPC) continue to represent major obstacles to long-term survival in head and neck cancer (HNC). Our aim was to evaluate whether established demographics, lifestyle-related risk factors for HNC and clinical data are associated with recurrence and SPC in HNC. We conducted a multicentre study by using data from five studies members of the International Head and Neck Cancer Epidemiology consortiumMilan, Rome, Western Europe, Sao Paulo, and Japan, totalling 4005 HNC cases with a median age of 59 (interquartile range 52-67). Multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for recurrence and SPC. During follow-up, 1161 (29%) patients had recurrence and 343 (8.6%) developed SPC. Advanced tumour stage was associated with increased risk of recurrence in HNC overall (HR=1.76, 95% CI 1.41-2.19). Women with laryngeal cancer had a reduced risk of recurrence compared to men (HR=0.39, 95% CI: 0.24-0.74). Concerning predictors of SPC, advanced age (HR=1.02; 95% CI: 1.00-1.04) and alcohol consumption (>1 drink per day, HR=2.11; 95% CI: 1.13-3.94) increased the risk of SPC among patients with laryngeal cancer. Additionally, women were at higher risk of SPC, in HNC overall group (HR=1.68; 95% CI: 1.13-2.51) and oropharyngeal cancer group (HR=1.74; 95% CI: 1.02-2.98). Tumour stage and male gender (larynx only) were positive predictors of cancer recurrence in HNC patients. Predictors of SPC were advanced age and alcohol use among laryngeal cancer cases, and female gender for oropharyngeal and HNC overall. (AU)

FAPESP's process: 04/12054-9 - Markers of aggressive behavior in head and neck tumors
Grantee:Eloiza Helena Tajara da Silva
Support type: Research Projects - Thematic Grants
FAPESP's process: 10/51168-0 - Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas
Grantee:Eloiza Helena Tajara da Silva
Support type: Research Projects - Thematic Grants