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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro SPF and Photostability Assays of Emulsion Containing Nanoparticles with Vegetable Extracts Rich in Flavonoids

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Author(s):
Cefali, Leticia Caramori [1, 2] ; Ataide, Janaina Artem [1, 3] ; Eberlin, Samara [4] ; da Silva Goncalves, Fernanda Cristina [4] ; Fernandes, Ana Rita [1] ; Marto, Joana [5] ; Ribeiro, Helena Margarida [5] ; Foglio, Mary Ann [6] ; Mazzola, Priscila Gava [6] ; Souto, Eliana Barbosa [1, 7]
Total Authors: 10
Affiliation:
[1] Univ Coimbra FFUC, Fac Pharm, Dept Pharmaceut Technol, Polo Ciencias Saude, P-3000548 Coimbra - Portugal
[2] Univ Estadual Campinas, UNICAMP, Inst Biol, Cidade Univ Zeferino Vaz, Monteiro Lobato St 255, BR-13083862 Campinas, SP - Brazil
[3] Univ Estadual Campinas, UNICAMP, Sch Med Sci, R Sergio Buarque de Holanda 250, BR-13083859 Campinas, SP - Brazil
[4] Kosmosci Grp, Rua Sandoval Meireles 72, BR-13041315 Campinas, SP - Brazil
[5] UL, Fac Pharm, Res Inst Med iMed ULisboa, P-1649003 Lisbon - Portugal
[6] Univ Estadual Campinas, UNICAMP, Fac Pharmaceut Sci, Rua Candido Portinari 200, BR-13083871 Campinas, SP - Brazil
[7] Univ Minho, Ctr Biol Engn, CEB, Campus Gualtar, P-4710057 Braga - Portugal
Total Affiliations: 7
Document type: Journal article
Source: AAPS PHARMSCITECH; v. 20, n. 1 JAN 2019.
Web of Science Citations: 4
Abstract

The aim of study was to determine the in vitro sun protection factor (SPF) and the photostability profile of a topical formulation composed of nanoparticles loaded with vegetable extracts and to assess its physicochemical properties. Chitosan/tripolyphosphate (TPP) nanoparticles loaded with flavonoids-enriched vegetable extracts (Ginkgo biloba L., Dimorphandra mollis Benth, Ruta graveolens, and Vitis vinifera L.) were produced and characterized for their morphology, mean particle size, zeta potential, and encapsulation efficiency. A final topical formulation was obtained by dispersing chitosan/TPP nanoparticles in an o/w emulsion. Results showed that nanoparticles dispersion exhibited yellowish color, spherical shape, and uniform appearance. Extract-loaded chitosan/TPP nanoparticles showed a mean particle size of 557.11 +/- 3.1nm, polydispersity index of 0.39 +/- 0.27, zeta potential of +11.54 +/- 2.1mV, and encapsulation efficiency of 75.89% of rutin. The recorded texture parameters confirm that the developed formulation is appropriate for skin application. The SPF obtained was 2.3 +/- 0.4, with a critical wavelength of 387.0nm and 0.69 UVA/UVB ratio. The developed formulation exhibited photostability, allowing the release of flavonoids from nanoparticles while retaining rutin into the skin in a higher extension. (AU)

FAPESP's process: 15/25533-7 - DEVELOPMENT AND EVALUATION OF A FLAVONOID ENRICHED EMULSION WITH SUN PROTECTION FACTOR
Grantee:Leticia Caramori Cefali
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/14757-7 - Development and evaluation of sun protection factor of emulsion containing extract rich in flavonoids
Grantee:Leticia Caramori Cefali
Support Opportunities: Scholarships abroad - Research Internship - Doctorate