| Full text | |
| Author(s): Show less - |
Durigon, Thomas Stravinskas
[1]
;
MacKenzie, BreAnne
[1]
;
Oliveira-Junior, Manoel Carneiro
[1]
;
Santos-Dias, Alana
[1]
;
De Angelis, Katia
[2]
;
Malfitano, Christiano
[3]
;
da Palma, Renata Kelly
[4]
;
Guerra, Juliana Moreno
[1]
;
Damaceno-Rodrigues, Nilsa Regina
[5]
;
Caldini, Elia Garcia
[5]
;
de Almeida, Francine Maria
[1]
;
Aquino-Santos, Helida Cristina
[6]
;
Rigonato-Oliveira, Nicole Cristine
[4]
;
Leal de Oliveira, Danielle Bruna
[7]
;
Aimbire, Flavio
[8]
;
Ligeiro de Oliveira, Ana Paula
[4]
;
Franco de Oliveira, Luiz Vicente
[9]
;
Durigon, Edison Luiz
[7]
;
Hiemstra, Pieter S.
[10]
;
Vieira, Rodolfo P.
[6, 1, 11]
Total Authors: 20
|
| Affiliation: Show less - | [1] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Jose Dos Campos - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo - Brazil
[3] Fed Univ Lavras UFLA, Sci Dept Hlth, Lavras - Brazil
[4] Nove de Julho Univ UNINOVE, Dept Hlth Sci, Sao Paulo - Brazil
[5] Univ Sao Paulo, Dept Pathol LIM 59, Sao Paulo - Brazil
[6] Univ Brasil, Postgrad Program Bioengn, Sao Paulo - Brazil
[7] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Lab Virol, Sao Paulo - Brazil
[8] Fed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Sao Jose Dos Campos - Brazil
[9] Unievangelica, Res Dept, Anapolis - Brazil
[10] Leiden Univ, Dept Pulmonol, Med Ctr, Leiden - Netherlands
[11] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Santos - Brazil
Total Affiliations: 11
|
| Document type: | Journal article |
| Source: | JOURNAL OF INNATE IMMUNITY; v. 10, n. 4, p. 279-290, 2018. |
| Web of Science Citations: | 2 |
| Abstract | |
Background: Pseudomonas aeruginosa (PS) infection results in severe morbidity and mortality, especially in immune-deficient populations. Aerobic exercise (AE) modulates the immune system, but its effects on the outcomes of pulmonary PS infection in elderly mice are unknown. Methods: BALB/c mice (24 weeks old) were randomized to sedentary, exercise (EX), PS, and PS + EX groups for the acute experimental setting, and PS and PS + EX groups for the chronic setting. Low-intensity AE was performed for 5 weeks, 60 min/day; 24 h after the final AE session, mice were inoculated with 5 x 10(4) colony-forming units (CFU) of PS, and 24 h and 14 days after PS inoculation, mice were studied. Results: AE inhibited PS colonization (p < 0.001) and lung inflammation (total cells, neutrophils, lymphocytes {[}p < 0.01] in bronchoalveolar lavage {[}BAL]), with significant differences in BAL levels of IL-1 beta (p < 0.001), IL-6 (p < 0.01), CXCL1 (p < 0.001), and TNF-alpha (p < 0.001), as well as parenchymal neutrophils (p < 0.001). AE increased BAL levels of IL-10 and parenchymal (p < 0.001) and epithelial (p < 0.001) IL-10 expression, while epithelial (p < 0.001) and parenchymal (p < 0.001) NF-kappa B expression was decreased. AE diminished pulmonary lipid peroxidation (p < 0.001) and increased glutathione peroxidase (p < 0.01). Preincubation of BEAS-2B with IL-10 inhibited PS-induced epithelial cell expression of TNF-alpha (p < 0.05), CD40 (p < 0.01), and dichlorodihydrofluorescein diacetate (p < 0.05). Conclusions: AE inhibits PS-induced lung inflammation and bacterial colonization in elderly mice, involving IL-10/ NF-.B, and redox signaling. (C) 2018 S. Karger AG, Basel (AU) | |
| FAPESP's process: | 12/16498-5 - Effect of low level laser therapy in experimental models of pulmonary chronic diseases |
| Grantee: | Ana Paula Ligeiro de Oliveira |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/08280-0 - Role of bronchial epithelium in the regulation of inflammation in asthma and COPD: new findings and state of art |
| Grantee: | Rodolfo de Paula Vieira |
| Support Opportunities: | Research Grants - Visiting Researcher Grant - International |
| FAPESP's process: | 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals |
| Grantee: | Rodolfo de Paula Vieira |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 14/23196-0 - The role of purinergic signalling and of SOCS-JAK-STAT signalling in the anti-inflammatory effects of aerobic training in asthmatic individuals. |
| Grantee: | Breanne Mackenzie |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 12/23305-9 - Effects of aerobic physical training on the chronic allergic pulmonary inflammation in mice: role of purinergic signaling |
| Grantee: | Flavia Regina Greiffo |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 14/14604-8 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in a model of asthma induced by house dust mite |
| Grantee: | Manoel Carneiro de Oliveira Junior |
| Support Opportunities: | Scholarships in Brazil - Doctorate |