| Full text | |
| Author(s): Show less - |
Odir Rodrigues Melo, Carlos Fernando
[1]
;
Navarro, Luiz Claudio
[2]
;
de Oliveira, Diogo Noin
[1]
;
Guerreiro, Tatiane Melina
[1]
;
Lima, Estela de Oliveira
[1]
;
Delafiori, Jeany
[1]
;
Dabaja, Mohamed Ziad
[1]
;
Ribeiro, Marta da Silva
[1]
;
de Menezes, Maico
[1]
;
Martins Rodrigues, Rafael Gustavo
[1]
;
Morishita, Karen Noda
[1]
;
Esteves, Cibele Zanardi
[1]
;
Lucas de Amorim, Aline Lopes
[1]
;
Aoyagui, Caroline Tiemi
[1]
;
Parise, Pierina Lorencini
[3]
;
Milanez, Guilherme Paier
[3]
;
do Nascimento, Gabriela Mansano
[3]
;
Ribas Freitas, Andre Ricardo
[4, 5]
;
Angerami, Rodrigo
[6]
;
Maranhao Costa, Fabio Trindade
[3]
;
Arns, Clarice Weis
[3]
;
Resende, Mariangela Ribeiro
[6]
;
Amaral, Eliana
[7]
;
Passini Junior, Renato
[7]
;
Ribeiro-do-Valle, Carolina C.
[7]
;
Milanez, Helaine
[7]
;
Moretti, Maria Luiza
[6]
;
Proenca-Modena, Jose Luiz
[3]
;
Avila, Sandra
[2]
;
Rocha, Anderson
[2]
;
Catharino, Rodrigo Ramos
[1]
;
Network, Zika-Unicamp
Total Authors: 32
|
| Affiliation: | [1] Univ Estadual Campinas, Sch Phannaceut Sci FCF, Innovate Biomarkers Lab, Campinas, SP - Brazil
[2] Univ Estadual Campinas, IC, RECOD Lab, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Biol Inst, Dept Genet Evolut Microbiol & Immunol, Campinas, SP - Brazil
[4] Sao Leopoldo Mandic Inst & Res Ctr, Campinas, SP - Brazil
[5] Campinas Dept Publ Hlth Surveillance, Campinas, SP - Brazil
[6] Univ Estadual Campinas, Sch Med Sci, Clin Pathol Dept, Campinas, SP - Brazil
[7] Univ Campinas Campinas, Sch Med Sci, Obstet & Gynecol Dept, Campinas, SP - Brazil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY; v. 6, APR 11 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
Recent Zika outbreaks in South America, accompanied by unexpectedly severe clinical complications have brought much interest in fast and reliable screening methods for ZIKV (Zika virus) identification. Reverse-transcriptase polymerase chain reaction (RT-PCR) is currently the method of choice to detect ZIKV in biological samples. This approach, none-theless, demands a considerable amount of time and resources such as kits and reagents that, in endemic areas, may result in a substantial financial burden over affected individuals and health services veering away from RT-PCR analysis. This study presents a powerful combination of high-resolution mass spectrometry and a machine-learning prediction model for data analysis to assess the existence of ZIKV infection across a series of patients that bear similar symptomatic conditions, but not necessarily are infected with the disease. By using mass spectrometry data that are inputted wrth the developed decision-making algorithm, we were able to provide a set of features that work as a ``fingerprint{''} for this specific pathophysiological condition, even after the acute phase of infection. Since both mass spectrometry and machine learning approaches are well-established and have largely utilized tools within their respective fields, this combination of methods emerges as a distinct alternative for clinical applications, providing a diagnostic screening-faster and more accurate-with improved cost-effectiveness when compared to existing technologies. (AU) | |
| FAPESP's process: | 14/00302-0 - Lipidomics shotgun in Giardiasis, Meningites and Tuberculosis: the search of diagnostic markers, using revolutionary new techniques of mass spectrometry. |
| Grantee: | Cibele Zanardi Esteves |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 11/50400-0 - Metabolismo energetico, estado redox e funcionalidade mitocondrial na morte celular e em desordens cardiometabolicas e neurodegenerativas. |
| Grantee: | Aníbal Eugênio Vercesi |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 15/06809-1 - Determination of chemical markers in various bovine products using mass spectrometry |
| Grantee: | Rodrigo Ramos Catharino |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/17066-2 - Metabolomics and lipidomics the Zika virus, from mosquitoes to the patient. |
| Grantee: | Carlos Fernando Odir Rodrigues Melo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/12646-3 - DéjàVu: Feature-Space-Time Coherence from Heterogeneous Data for Media Integrity Analytics and Interpretation of Events |
| Grantee: | Anderson de Rezende Rocha |
| Support Opportunities: | Research Projects - Thematic Grants |