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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Analysis of the effects of mesoporous silica particles SBA-15 and SBA-16 in Streptococcus pneumoniae transformation process

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Amstalden, Maria-Cecilia Krahenbuehl [1, 2] ; Oliveira, Jose Diogo [1] ; Strauss, Mathias [3, 4] ; Mazali, Italo Odone ; Machado, Daisy [1] ; Theisen, Thais Holtz [1] ; Lancellotti, Marcelo [1, 2]
Total Authors: 7
[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Inst Chem, Funct Mat Lab, Campinas, SP - Brazil
[4] Natl Ctr Res Energy & Mat, Brazilian Nanotechnol Natl Lab, Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Folia Microbiologica; v. 64, n. 1, p. 127-132, JAN 2019.
Web of Science Citations: 0

Streptococcus pneumoniae are natural competent bacteria which requires the presence of a pheromone-like molecule to do the transformation process. This study verified the influence of mesoporous silica (SBA-15 and SBA-16) on the transformation process in S. pneumoniae using a donor DNA obtained from a mutant strain of this microorganism (Sp360luxS). The results showed that mesoporous silica SBA-15 and SBA-16 particles doubled the transformation ratio frequency compared with negative control (without nanoparticles) in using SBA-15 (ratio 1.81 +/- 0.04) and SBA-16 (ratio 2.18 +/- 0.22). We demonstrated the how mesoporous silica nanoparticles were able to increase the pneumococcus transformations, which could possibly lead to the acquisition of virulence factor genes and resistance of antibiotics. (AU)

FAPESP's process: 14/50906-9 - INCT 2014: in Functional Complex Materials
Grantee:Fernando Galembeck
Support type: Research Projects - Thematic Grants
FAPESP's process: 11/14079-2 - Use of nanoparticles in vaccines against bacterial meningitis
Grantee:Marcelo Lancellotti
Support type: Regular Research Grants
FAPESP's process: 13/22127-2 - Development of novel materials strategic for integrated analytical devices
Grantee:Lauro Tatsuo Kubota
Support type: Research Projects - Thematic Grants