| Full text | |
| Author(s): |
Amstalden, Maria-Cecilia Krahenbuehl
[1, 2]
;
Oliveira, Jose Diogo
[1]
;
Strauss, Mathias
[3, 4]
;
Mazali, Italo Odone
;
Machado, Daisy
[1]
;
Theisen, Thais Holtz
[1]
;
Lancellotti, Marcelo
[1, 2]
Total Authors: 7
|
| Affiliation: | [1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Inst Chem, Funct Mat Lab, Campinas, SP - Brazil
[4] Natl Ctr Res Energy & Mat, Brazilian Nanotechnol Natl Lab, Campinas, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Folia Microbiologica; v. 64, n. 1, p. 127-132, JAN 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Streptococcus pneumoniae are natural competent bacteria which requires the presence of a pheromone-like molecule to do the transformation process. This study verified the influence of mesoporous silica (SBA-15 and SBA-16) on the transformation process in S. pneumoniae using a donor DNA obtained from a mutant strain of this microorganism (Sp360luxS). The results showed that mesoporous silica SBA-15 and SBA-16 particles doubled the transformation ratio frequency compared with negative control (without nanoparticles) in using SBA-15 (ratio 1.81 +/- 0.04) and SBA-16 (ratio 2.18 +/- 0.22). We demonstrated the how mesoporous silica nanoparticles were able to increase the pneumococcus transformations, which could possibly lead to the acquisition of virulence factor genes and resistance of antibiotics. (AU) | |
| FAPESP's process: | 14/50906-9 - INCT 2014: in Functional Complex Materials |
| Grantee: | Fernando Galembeck |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 11/14079-2 - Use of nanoparticles in vaccines against bacterial meningitis |
| Grantee: | Marcelo Lancellotti |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/22127-2 - Development of novel materials strategic for integrated analytical devices |
| Grantee: | Lauro Tatsuo Kubota |
| Support Opportunities: | Research Projects - Thematic Grants |