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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New Perspectives on Chlorogenic Acid Accumulation in Harvested Leaf Tissue: Impact on Traditional Medicine Preparations

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Author(s):
Moreira, Duarda Antunes [1] ; Pilon, Alan Cesar [1] ; Andrade, Laura Elena [1] ; Lopes, Norberto Peporine [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, NPPNS, Ave Cafe S-N, BR-14040903 Ribeirao Preto - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ACS OMEGA; v. 3, n. 12, p. 18380-18386, DEC 2018.
Web of Science Citations: 0
Abstract

Chlorogenic acids (CGAs) are known as an important class of natural products found in different plant species and are of great interest in diverse research fields. Described as powerful antioxidant agents, these compounds can be found in high concentrations in commonly consumed foods and beverages and in herbal preparations traditionally used in Chinese, Ayurvedic, European, and popular medicines from the new world and are responsible for several pharmacological activities. Considering that diverse mechanisms may possibly be involved in plant metabolite production, herein we evaluated if CGA postharvest accumulation can be a consequence of processes other than anabolism. The objective was to compare the concentrations of chlorogenic acids in leaves subjected to different time-controlled periods of drying at room temperature. A quantitative method, using ultraperformance liquid chromatography tandem mass spectrometry, was developed to monitor the content of CGAs in coffee, lemon, Brazilian cherry, and rosemary leaves. Caffeoylquinic, feruloylquinic, and p-coumaroylquinic acids were accumulated throughout 30 days of postharvest drying in all of the studied species. The results indicate that soft drying is crucial for the accumulation of chlorogenic acids and that their content in plant material may be a consequence of more than just anabolic mechanisms. Knowing that other processes such as catabolism and turnover reactions may participate in the accumulation of natural products, it is possible to discuss the mechanisms that lead to higher concentrations of pharmacologically important substances in different plant species, including plants traditionally used in folk medicine. (AU)

FAPESP's process: 14/50265-3 - Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation
Grantee:Norberto Peporine Lopes
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 15/09227-3 - Analysis of the metabolism variation of chlorogenic acid and its derivatives
Grantee:Eduarda Antunes Moreira
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 10/17935-4 - Development of analytical methods of dereplication by NMR and multivaried analysis of metabolomic profile from Solanaceae species with bioactive potential
Grantee:Alan Cesar Pilon
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/13292-8 - Analysis of nitrogen content in antropic influenced areas in Amazon and Atlantic Forest using a metabolomic tools
Grantee:Alan Cesar Pilon
Support Opportunities: Scholarships in Brazil - Post-Doctoral