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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of periodontal treatment on Aggregatibacter actinomycetemcomitans colonization and serum IgG levels against A-actinomycetemcomitans serotypes and Omp29 of aggressive periodontitis patients

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Author(s):
Rebeis, Estela Sanches [1] ; Albuquerque-Souza, Emmanuel [1] ; da Silva, Maike Paulino [2] ; Giudicissi, Marcela [1] ; Mayer, Marcia P. A. [2, 1] ; Saraiva, Luciana [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Dent, Dept Stomatol, Div Periodont, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ORAL DISEASES; v. 25, n. 2, p. 569-579, MAR 2019.
Web of Science Citations: 1
Abstract

Objective To evaluate the effect of the periodontal treatment on Aggregatibacter actinomycetemcomitans JP2 clone, and the IgG serum levels against its outer membrane protein (Omp29) and A. actinomycetemcomitans serotypes in aggressive periodontitis (AgP). Subjects and Methods Seventeen patients with generalized (GAgP), 10 with localized (LAgP), and 10 healthy controls were included. AgP participants were submitted to periodontal treatment-scaling and root planing plus antibiotics (SRP+A). Periodontal parameters, for example, probing depth (PD) and clinical attachment loss (CAL), were evaluated at baseline and at 1-year. Serum IgG against Omp29 and serotypes a, b, and c were determined by ELISA. The levels of A. actinomycetemcomitans JP2 clone were determined in subgingival biofilm samples by qPCR. Results Periodontal treatment resulted in significant reductions of PD, CAL, and IgG levels against Omp29, serotypes b, and c. After therapy, IgG levels against A. actinomycetemcomitans serotypes, as well as the levels of the JP2 clone in AgP, became similar to controls. The reduction in JP2 clone count was correlated with a reduction of PD and IgG response against Omp29. Conclusion Scaling and root planing plus antibiotics decreased IgG levels response against Omp29 and A. actinomycetemcomitans serotypes involved in the disease (b and c), while the serum response increased against tne commensal serotype (a), similar to what occurs in periodontally healthy individuals. (AU)

FAPESP's process: 13/26381-0 - Analysis of cytokines (in gingival fluid and serum) and periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) in patients with aggressive periodontitis. longitudinal study
Grantee:Luciana Saraiva
Support Opportunities: Regular Research Grants
FAPESP's process: 12/05911-9 - Aggregatibacter actinomycetemcomitans: analysis of the virulence and the transcriptomes of strains of JP2-like and non-JP2 serotype b lineages in the induction of experimental peri-implantitis in animal
Grantee:Maike Paulino da Silva
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 10/16162-1 - Analysis of serum IgG response against OMP29 and whole cell of A. actinomycetemcomitans of different serotypes and against whole cell of P. gingivalis and T. forsythia in patients with aggressive periodontitis
Grantee:Luciana Saraiva
Support Opportunities: Regular Research Grants