An LDI-MSI approach for targeted and untargeted differentiation and assessment of pharmaceutical formulations

Author(s)

Godoy Falco, Luis Fernando ^[1] ; Odir Rodrigues Melo, Carlos Fernando ^{[1, 2]} ; de Oliveira, Diogo Noin ^[1] ; Guerreiro, Tatiane Melina ^[1] ; Catharino, Rodrigo Ramos ^[1]

Affiliation

^[1] Univ Estadual Campinas, Sch Pharmaceut Sci, Innovare Biomarkers Lab, BR-13083877 Campinas, SP - Brazil

^[2] Superintendencia Policia Tecnicocient, BR-05507060 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Talanta; v. 197, p. 92-97, MAY 15 2019.
• Web of Science Citations: 0

Abstract

Falsified, counterfeit and adulterated medicines are an endemic problem worldwide that results in both monetary and health-related losses. Developing fast and reliable methods that are able to present a timely result based on the drug's spectral profile is an effort that is sure to benefit those involved in the whole distribution chain. We propose herein a Laser Desorption/Ionization imaging-based method that provides simple and minimal sample preparation; this method is capable of providing specific markers that characterize adulterations, using as proof of concept one of the most adulterated drug products for oral use, sildenafil. Our approach is able to provide quality markers, which can be applied in the fast screening of any product within the same molecular class. This same strategy may be a useful alternative to provide accurate measurements with high specificity for unraveling contaminants and/or byproducts in virtually any given pharmaceutical product. (AU)

• FAPESP's process: 11/50400-0 - Mitochondrial energy metabolism, redox state and functionality in cell death and cardiometabolic and neurodegenerative disorders
• Grantee: Aníbal Eugênio Vercesi
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/06809-1 - Determination of chemical markers in various bovine products using mass spectrometry
• Grantee: Rodrigo Ramos Catharino
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/17066-2 - Metabolomics and lipidomics the Zika virus, from mosquitoes to the patient
• Grantee: Carlos Fernando Odir Rodrigues Melo
• Support Opportunities: Scholarships in Brazil - Doctorate