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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An LDI-MSI approach for targeted and untargeted differentiation and assessment of pharmaceutical formulations

Full text
Author(s):
Godoy Falco, Luis Fernando [1] ; Odir Rodrigues Melo, Carlos Fernando [1, 2] ; de Oliveira, Diogo Noin [1] ; Guerreiro, Tatiane Melina [1] ; Catharino, Rodrigo Ramos [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Sch Pharmaceut Sci, Innovare Biomarkers Lab, BR-13083877 Campinas, SP - Brazil
[2] Superintendencia Policia Tecnicocient, BR-05507060 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Talanta; v. 197, p. 92-97, MAY 15 2019.
Web of Science Citations: 0
Abstract

Falsified, counterfeit and adulterated medicines are an endemic problem worldwide that results in both monetary and health-related losses. Developing fast and reliable methods that are able to present a timely result based on the drug's spectral profile is an effort that is sure to benefit those involved in the whole distribution chain. We propose herein a Laser Desorption/Ionization imaging-based method that provides simple and minimal sample preparation; this method is capable of providing specific markers that characterize adulterations, using as proof of concept one of the most adulterated drug products for oral use, sildenafil. Our approach is able to provide quality markers, which can be applied in the fast screening of any product within the same molecular class. This same strategy may be a useful alternative to provide accurate measurements with high specificity for unraveling contaminants and/or byproducts in virtually any given pharmaceutical product. (AU)

FAPESP's process: 11/50400-0 - Mitochondrial energy metabolism, redox state and functionality in cell death and cardiometabolic and neurodegenerative disorders
Grantee:Aníbal Eugênio Vercesi
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/06809-1 - Determination of chemical markers in various bovine products using mass spectrometry
Grantee:Rodrigo Ramos Catharino
Support Opportunities: Regular Research Grants
FAPESP's process: 16/17066-2 - Metabolomics and lipidomics the Zika virus, from mosquitoes to the patient
Grantee:Carlos Fernando Odir Rodrigues Melo
Support Opportunities: Scholarships in Brazil - Doctorate