| Full text | |
| Author(s): Show less - |
Protachevicz, Paulo R.
[1]
;
Borges, Fernando S.
[2]
;
Lameu, Ewandson L.
[3]
;
Ji, Peng
[4, 5]
;
Iarosz, Kelly C.
[6]
;
Kihara, Alexandre H.
[2]
;
Caldas, Lbere L.
[6]
;
Szezech Jr, Jose D.
;
Baptiste, Murilo S.
[7]
;
Macau, Elbert E. N.
[3]
;
Antonopoulos, Chris G.
[8]
;
Batista, Antonio M.
[9, 10]
;
Kurthsw, Juergen
[11, 12]
Total Authors: 13
|
| Affiliation: Show less - | [1] Univ Estadual Ponta Grossa, Grad Sci Program Phys, Ponta Grossa - Brazil
[2] Fed Univ ABC, Ctr Math Computat & Cognit, Sao Bernardo Do Campo - Brazil
[3] Natl Inst Space Res, Sao Jose Dos Campos - Brazil
[4] Fudan Univ, Minist Educ, Key Lab Computat Neurosci & Brain Inspired Intell, Shanghai - Peoples R China
[5] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai - Peoples R China
[6] Univ Sao Paulo, Inst Phys, Sao Paulo - Brazil
[7] Univ Aberdeen, SUPA, Inst Complex Syst & Math Biol, Aberdeen - Scotland
[8] Univ Essex, Dept Math Sci, Colchester, Essex - England
[9] Szezech Jr, Jr., Jose D., Univ Estadual Ponta Grossa, Grad Sci Program Phys, Ponta Grossa - Brazil
[10] Szezech Jr, Jr., Jose D., Univ Estadual Ponta Grossa, Dept Math & Stat, Ponta Grossa - Brazil
[11] Humboldt Univ, Dept Phys, Berlin - Germany
[12] Potsdam Inst Climate Impact Res, Potsdam - Germany
Total Affiliations: 12
|
| Document type: | Journal article |
| Source: | FRONTIERS IN COMPUTATIONAL NEUROSCIENCE; v. 13, APR 5 2019. |
| Web of Science Citations: | 2 |
| Abstract | |
Excessively high, neural synchronization has been associated with epileptic seizures, one of the most common brain diseases worldwide. A better understanding of neural synchronization mechanisms can thus help control or even treat epilepsy. In this paper, we study neural synchronization in a random network where nodes are neurons with excitatory and inhibitory synapses, and neural activity for each node is provided by the adaptive exponential integrate-and-fire model. In this framework, we verify that the decrease in the influence of inhibition can generate synchronization originating from a pattern of desynchronized spikes. The transition from desynchronous spikes to synchronous bursts of activity, induced by varying the synaptic coupling, emerges in a hysteresis loop due to bistability where abnormal (excessively high synchronous) regimes exist. We verify that, for parameters in the bistability regime, a square current pulse can trigger excessively high (abnormal) synchronization, a process that can reproduce features of epileptic seizures. Then, we show that it is possible to suppress such abnormal synchronization by applying a small-amplitude external current on > 10% of the neurons in the network. Our results demonstrate that external electrical stimulation not only can trigger synchronous behavior, but more importantly, it can be used as a means to reduce abnormal synchronization and thus, control or treat effectively epileptic seizures. (AU) | |
| FAPESP's process: | 17/18977-1 - Analysis of Electrical Synapses Contribution in Neuronal Synchronization |
| Grantee: | Fernando da Silva Borges |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/23398-8 - Synaptic plasticity in neuronal networks with time delay |
| Grantee: | Ewandson Luiz Lameu |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/16148-5 - Synchronous behaviour and synaptic plasticity in complex networks |
| Grantee: | Kelly Cristiane Iarosz |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 15/07311-7 - Dynamic behaviour of neural networks |
| Grantee: | Kelly Cristiane Iarosz |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/13502-5 - Synchronisation in time-delayed networks with synaptic plasticity |
| Grantee: | Ewandson Luiz Lameu |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 15/50122-0 - Dynamic phenomena in complex networks: basics and applications |
| Grantee: | Elbert Einstein Nehrer Macau |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/03211-6 - Non linear dynamics |
| Grantee: | Iberê Luiz Caldas |
| Support Opportunities: | Research Projects - Thematic Grants |