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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of intermittent teriparatide (PTH 1-34) on the alveolar healing process in orchiectomized rats

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Author(s):
de Oliveira, Danila [1] ; Puttini, Igor de Oliveira [2, 3] ; Silva Gomes-Ferreira, Pedro Henrique [2, 3] ; Palin, Leticia Pitol [1] ; Matsumoto, Mariza Akemi [1] ; Okamoto, Roberta [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Paulista UNESP, Aracatuba Dent Sch, Dept Basic Sci, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
[2] Univ Estadual Paulista UNESP, Aracatuba Dent Sch, Dept Surg, Aracatuba, SP - Brazil
[3] Univ Estadual Paulista UNESP, Aracatuba Dent Sch, Integrated Clin, Aracatuba, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: CLINICAL ORAL INVESTIGATIONS; v. 23, n. 5, p. 2313-2322, MAY 2019.
Web of Science Citations: 1
Abstract

ObjectiveTo evaluate intermittent teriparatide therapy's influence on the alveolar healing process in rats with induced osteoporosis.Materials and methodsFifty-four male rats were divided into three groups: fictitious surgery (SHAM), bilateral orchiectomy (ORQ NT), and bilateral orchiectomy treated with teriparatide (ORQ TERI). Right upper incisor extraction was performed. After 14 and 42days, the rats were euthanized. Immunolabeling analysis was performed in order to characterize bone turnover through Wnt, alcaline phosphatase, osteocalcin, and TRAP presence in tissue; micro-CT analysis was performed in order to determine the bone volume fraction (BV/TV), trabecular thickness, separation, and number (Tb.Th, Tb.Sp, Tb.N). For the micro-CT data, statistical analysis was performed through one-way ANOVA and Tukey post-test, for parametrical data, with significance level adopted in p<0.05. Days, Wnt, alkaline phosphatase, and osteocalcin revealed more labeling for ORQ TERI and less for TRAP. For the Tb.N in the ORQ NT group was 0.496mm, a significant statistical difference was observed between the groups of ORQ NT and ORQ TERI (p<0.05). For the BV/TV, Tb.Sp, and Tb.Th parameters, no significant statistical difference was observed among the three experimental groups (p>0.05).ConclusionsTreatment with intermittent teriparatide reverted impairment in the metabolism of repairing bone tissue in orchiectomized animals.Clinical relevanceCases of decreased bone density such as osteoporosis can lead to delayed alveolar repair process. PTH 1-34 has been shown to be a medication that improves this repair, making bone of low quality into one with normal features. (AU)

FAPESP's process: 15/20203-9 - Effect of the teriparatide in the alveolar bone repair process in orchiectomy rats: analysis immunohistochemical, histometrical and tridimensional microtomography.
Grantee:Danila de Oliveira
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/14688-0 - Characterization of bone tissue formed during the alveolar bone repair and osseointegration process in rats submited to anti-osteoporosis therapy. histological, histometrical, immunohistochemical, molecular and tridimensional aspects.
Grantee:Roberta Okamoto
Support type: Regular Research Grants