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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment

Full text
Author(s):
Morise, B. T. [1] ; Chagas, A. L. D. [2, 1] ; Barros, N. R. [2, 1] ; Miranda, M. C. R. [1] ; Borges, F. A. [2, 1] ; Gemeinder, J. L. P. [2] ; Silva, R. G. [2] ; Paulino, C. G. [1] ; Herculano, R. D. [1] ; Norberto, A. M. Q. [3]
Total Authors: 10
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara Km 01, Araraquara Jau Rd, BR-14801902 Araraquara - Brazil
[2] Sao Paulo State Univ UNESP, Inst Chem, 55 Prof Francisco Degni St, BR-14800900 Araraquara - Brazil
[3] Univ Sao Paulo, Fac Med, Ribeirao Preto - Brazil
Total Affiliations: 3
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS; v. 68, n. 13, p. 788-795, SEP 2 2019.
Web of Science Citations: 1
Abstract

Sialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membranes carried with scopolamine butylbromide, using optical spectroscopy, Infrared spectroscopy, wettability, Scanning Electron Microscopy and hemolytic assays. The kinetic profile of scopolamine butylbromide showed that matrix released 96.49% of the drug and tests showed no hemolytic effects. Physico-chemical characterization and tensile tests showed that this system is a potential alternative for the treatment of sialorrhea. (AU)

FAPESP's process: 14/17526-8 - Development of a novel system employing natural rubber latex as releasing of vegetable extracts incorporated with nanoparticles: physical chemical and biological characterization
Grantee:Rondinelli Donizetti Herculano
Support Opportunities: Regular Research Grants
FAPESP's process: 11/17411-8 - Evaluation of drugs delivery systems using natural rubber latex membranes as carrier
Grantee:Rondinelli Donizetti Herculano
Support Opportunities: Regular Research Grants