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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dynapenic Abdominal Obesity as a Risk Factor for Worse Trajectories of ADL Disability Among Older Adults: The ELSA Cohort Study

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Author(s):
Alexandre, Tiago da Silva [1, 2] ; Scholes, Shaun [1] ; Ferreira Santos, Jair Licio [3] ; de Oliveira, Cesar [1]
Total Authors: 4
Affiliation:
[1] UCL, Dept Epidemiol & Publ Hlth, London - England
[2] Univ Fed Sao Carlos, Dept Gerontol, Rodovia Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Dept Social Med, Ribeirao Preto - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES; v. 74, n. 7, p. 1112-1118, JUL 2019.
Web of Science Citations: 1
Abstract

Background: There is little epidemiological evidence demonstrating that dynapenic abdominal obese individuals have worse trajectories of disability than those with dynapenia and abdominal obesity alone. Our aim was to investigate whether dynapenic abdominal obesity can result in worse trajectories of activities of daily living (ADL.) over 8 years of follow-up. Methods: We used longitudinal data from 3,723 participants free from ADL disability at baseline from the English Longitudinal Study of Ageing. Using measures of handgrip strength (<26 kg for men; <16 kg for women) and waist circumference (>102 cm for men; >88 cm for women), participants were classified into four groups: nondynapenic/nonabdominal obese (reference group), abdominal obese only, dynapenic only, and dynapenic abdominal obese. We used generalized linear mixed models with ADL as the outcome and the four groups according to dynapenia and abdominal obesity status as the main exposure controlled by sociodemographic, behavioral, and clinical characteristics. Results: The estimated change over time in ADL disability was significantly higher for participants with dynapenic abdominal obesity compared with those with neither condition (+0.018, 95% CI: 0.008 to 0.027). Compared with the results of our main analysis (which took into account the combination of dynapenia and abdominal obesity on the rate of change in ADL), the results of our sensitivity analysis-which examined dynapenia and abdominal obesity only as independent conditions-showed an overestimation of the associations of dynapenia only and of abdominal obesity only on the ADL disability trajectories. Conclusions: Dynapenic abdominal obesity is an important risk factor for functional decline in older adults. (AU)

FAPESP's process: 15/20294-4 - The addictive effect of dynapenia and obesity (dynapenic obesity) on the incidence of disability and mortality among older adults: a comparison between Brazil and England
Grantee:Tiago da Silva Alexandre
Support type: Scholarships abroad - Research