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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Analysis of 8q24.21 miRNA cluster expression and copy number variation in gastric cancer

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Anauate, Ana C. [1] ; Leal, Mariana F. [1] ; Wisnieski, Fernanda [1, 2] ; Santos, Leonardo C. [1] ; Gigek, Carolina O. [1, 3] ; Chen, Elizabeth S. [1] ; Calcagno, Danielle Q. [4] ; Assumpcao, Paulo P. [4] ; Demachki, Samia [4] ; Arasaki, Carlos H. [3] ; Artigiani, Ricardo [5] ; Rasmussen, Lucas T. [6] ; Payao, Spencer M. [6] ; Burbano, Rommel R. [4, 7, 8] ; Smith, Marilia A. C. [1]
Total Authors: 15
[1] Univ Fed Sao Paulo, Dept Morfol & Genet, Disciplina Genet, BR-04023900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Med, Disciplina Gastroenterol, BR-04040002 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Cirurgia, Disciplina Gastroenterol Cirug, BR-04024002 Sao Paulo - Brazil
[4] Univ Fed Para, Hosp Univ Joao de Barros Barreto, Nucleo Pesquisas Oncol, BR-66073000 Belem, Para - Brazil
[5] Univ Fed Sao Paulo, Dept Patol, BR-04023062 Sao Paulo - Brazil
[6] Fac Med Marilia, Dept Genet & Biol Mol, BR-17519050 Marilia - Brazil
[7] Univ Fed Para, Inst Ciencias Biol, Lab Citogenet Humana, BR-66075110 Belem, Para - Brazil
[8] Hosp Ophir Loyola, Lab Biol Mol, BR-66063240 Belem, Para - Brazil
Total Affiliations: 8
Document type: Journal article
Source: Future Medicinal Chemistry; v. 11, n. 9, p. 947-958, MAY 2019.
Web of Science Citations: 3

Aim: To analyze gene expression and copy number of five miRNAs (miR-1204, miR-1205, miR-1206, miR-1207 and miR-1208) localized in this chromosome region in gastric cancer (GC). Materials\& methods: 65 paired neoplastic and non-neoplastic specimens collected from GC patients and 20 non-neoplastic gastric tissues from cancer-free individuals were included in this study. The expression levels of the five miRNAs were accessed by real time qPCR and were correlated. Results: MiR-1207-3p, miR-1205, miR-1207-5p and miR-1208 were upregulated in approximately 50% of GC tumors in relation to those of adjacent non-neoplastic tissues. MiR-1205 expression was associated with gain of gene copies and was upregulated in adjacent non-neoplastic samples relative to external controls. Conclusion: The coexpression of the 8q24 miRNAs indicated the role of miR-1205 in the initiation of gastric cancer development. (AU)

FAPESP's process: 16/19953-6 - Epigenetically modulated genes may constitute therapeutic targets in patients with gastric cancer?
Grantee:Fernanda Wisnieski
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/14768-5 - Nontraumatic orthopedic conditions of shoulder: genetic and molecular aspects
Grantee:Mariana Ferreira Leal
Support type: Scholarships in Brazil - Young Researchers