Analysis of 8q24.21 microRNAs expression in gastric carcinogenesis
| Full text | |
| Author(s): Show less - |
Anauate, Ana C.
[1]
;
Leal, Mariana F.
[1]
;
Wisnieski, Fernanda
[1, 2]
;
Santos, Leonardo C.
[1]
;
Gigek, Carolina O.
[1, 3]
;
Chen, Elizabeth S.
[1]
;
Calcagno, Danielle Q.
[4]
;
Assumpcao, Paulo P.
[4]
;
Demachki, Samia
[4]
;
Arasaki, Carlos H.
[3]
;
Artigiani, Ricardo
[5]
;
Rasmussen, Lucas T.
[6]
;
Payao, Spencer M.
[6]
;
Burbano, Rommel R.
[4, 7, 8]
;
Smith, Marilia A. C.
[1]
Total Authors: 15
|
| Affiliation: | [1] Univ Fed Sao Paulo, Dept Morfol & Genet, Disciplina Genet, BR-04023900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Med, Disciplina Gastroenterol, BR-04040002 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Cirurgia, Disciplina Gastroenterol Cirug, BR-04024002 Sao Paulo - Brazil
[4] Univ Fed Para, Hosp Univ Joao de Barros Barreto, Nucleo Pesquisas Oncol, BR-66073000 Belem, Para - Brazil
[5] Univ Fed Sao Paulo, Dept Patol, BR-04023062 Sao Paulo - Brazil
[6] Fac Med Marilia, Dept Genet & Biol Mol, BR-17519050 Marilia - Brazil
[7] Univ Fed Para, Inst Ciencias Biol, Lab Citogenet Humana, BR-66075110 Belem, Para - Brazil
[8] Hosp Ophir Loyola, Lab Biol Mol, BR-66063240 Belem, Para - Brazil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Future Medicinal Chemistry; v. 11, n. 9, p. 947-958, MAY 2019. |
| Web of Science Citations: | 3 |
| Abstract | |
Aim: To analyze gene expression and copy number of five miRNAs (miR-1204, miR-1205, miR-1206, miR-1207 and miR-1208) localized in this chromosome region in gastric cancer (GC). Materials\& methods: 65 paired neoplastic and non-neoplastic specimens collected from GC patients and 20 non-neoplastic gastric tissues from cancer-free individuals were included in this study. The expression levels of the five miRNAs were accessed by real time qPCR and were correlated. Results: MiR-1207-3p, miR-1205, miR-1207-5p and miR-1208 were upregulated in approximately 50% of GC tumors in relation to those of adjacent non-neoplastic tissues. MiR-1205 expression was associated with gain of gene copies and was upregulated in adjacent non-neoplastic samples relative to external controls. Conclusion: The coexpression of the 8q24 miRNAs indicated the role of miR-1205 in the initiation of gastric cancer development. (AU) | |
| FAPESP's process: | 16/19953-6 - Epigenetically modulated genes may constitute therapeutic targets in patients with gastric cancer? |
| Grantee: | Fernanda Wisnieski |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 12/14768-5 - Nontraumatic orthopedic conditions of shoulder: genetic and molecular aspects |
| Grantee: | Mariana Ferreira Leal |
| Support type: | Scholarships in Brazil - Young Researchers |