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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lapachol biotransformation by filamentous fungi yields bioactive quinone derivatives and lapachol-stimulated secondary metabolites

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Author(s):
Coitinho, Luciana Barbosa [1] ; Fumagalli, Fernando [1] ; da Rosa-Garzon, Nathalia Gonsales [1] ; Emery, Flavio da Silva [1] ; Cabral, Hamilton [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto - Brazil
Total Affiliations: 1
Document type: Journal article
Source: PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY; v. 49, n. 5, p. 459-463, MAY 28 2019.
Web of Science Citations: 1
Abstract

Lapachol is a natural naphthoquinone with a range of biological effects, including anticancer activity. Microbial transformations of lapachol can lead to the formation of new biologically active compounds. In addition, fungi can produce secondary metabolites that are also important for drug discovery. The goal of this study was to evaluate the ability of filamentous fungi to biotransform lapachol into biologically active compounds and identify secondary metabolites produced in the presence of lapachol. Seven out of nine strains of filamentous fungi tested exhibited the ability to biotransform or biodegrade lapachol. The bioactive derivatives norlapachol and isolapachol were identified among biotransformation products. Moreover, lapachol stimulated the production of pyrrolo-{[}1,2-a] pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl) and phenol-2,4-bis-(1,1-dimethylethyl), secondary metabolites already known to have antimicrobial and antioxidant activities. These results open the perspective of using these strains of filamentous fungi for lapachol biotransformation and efficient production of several biologically active compounds. (AU)

FAPESP's process: 14/01497-9 - Biotransformation of lapachol by filamentous fungi: proteomic analysis for identification to biotransformation route
Grantee:Luciana Barbosa Coitinho
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/24703-8 - Proteomics analyses of meso and thermophilic filamentous fungi exposed to physical and chemical factors
Grantee:Hamilton Cabral
Support Opportunities: Regular Research Grants