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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Presence of circulating folic acid in plasma and its relation with dietary intake, vitamin B complex concentrations and genetic variants

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Author(s):
Steluti, Josiane [1] ; Reginaldo, Christina [2] ; Selhub, Jacob [2] ; Paul, Ligi [2] ; Fisberg, Regina Mara [1] ; Marchioni, Dirce Maria [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil
[2] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 - USA
Total Affiliations: 2
Document type: Journal article
Source: EUROPEAN JOURNAL OF NUTRITION; v. 58, n. 8, p. 3069-3077, DEC 2019.
Web of Science Citations: 2
Abstract

PurposeThe aim of this study was to investigate circulating folic acid (FA) and predict circulating FA concentrations in the population related to dietary intake, vitamin concentrations, and interaction with the genetic variants involved in folate metabolism.MethodsData were from the `Health Survey of SAo Paulo' a cross-sectional population-based survey, conducted in SAo Paulo City, Brazil. The participants (n=750) provided fasting blood samples and food intake data. Folate, homocysteine, and B6 and B12 vitamins were assayed. DNA was isolated, and the genotypes for polymorphisms involved in folate metabolism were determined. A generalized linear model was performed to predict circulating FA concentration.ResultsThe circulating FA was detected in 80.0% of the population, with a median concentration of 1.6 nmol/L (IQR 0.5-2.9). The increase of circulating FA concentrations was directly associated with total folate concentration (beta coeff. 1.03; 95% CI 1.02-1.04), age (beta coeff. 1.01; 95% CI 1.01-1.02), current smoker (beta coeff. 1.51; 95% CI 1.16-1.97), self-reported skin color (beta coeff. 1.83; 95% CI 1.51-2.20), as well as interaction between folate concentration and 19-bp deletion polymorphism in DHFR (beta coeff. 1.02; 95% CI 1.01-1.03), and inversely associated with vitamin B6 (beta coeff. 0.99; 95% CI 0.98-0.99).ConclusionsIn the current study, the presence of detectable circulating folic acid is high, and its concentration is elevated compared with other populations. Age, smoking, lower concentration of vitamin B6 and genetic variant are associated with increased levels of circulating FA. Further researches are needed to acknowledge and guarantee the safety of exposure to folic acid, especially in countries which have mandatory fortification. (AU)

FAPESP's process: 11/19788-1 - Assessment of folate status after mandatory folic acid fortification and health consequences: population-based study in the City of São Paulo
Grantee:Dirce Maria Lobo Marchioni
Support type: Regular Research Grants
FAPESP's process: 15/12196-2 - UNMETABOLIZED FOLIC ACID AND ITS ASSOCIATIONS WITH GLOBAL DNA METHYLATION, OXIDATIVE STRESS, INFLAMMATORY MARKERS AND METABOLIC SIGNATURE: ANALYSIS AFTER MANDATORY FORTIFICATION OF FLOUR WITH FOLIC
Grantee:Josiane Steluti
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/05505-0 - Standardization of methodology and analysis of unmetabolized folic acid after mandatory fortification with folic acid: population-based study in São Paulo City
Grantee:Josiane Steluti
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 10/19899-5 - Dietary intake and genetic variants of folate and its relation to folate, unmetabolized folic acid and homocysteine blood concentrations after mandoty folic acid fortification: population based study - ISA-Capital.
Grantee:Josiane Steluti
Support type: Scholarships in Brazil - Doctorate