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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Galectin-3 Expression Correlates with Post-surgical Survival in Canine Oral Melanomas

Full text
Author(s):
Vargas, T. H. M. [1] ; Pulz, L. H. [2, 1] ; Ferro, D. G. [3] ; Sobral, R. A. [4] ; Venturini, M. A. F. A. [3] ; Correa, H. L. [3] ; Strefezzi, R. F. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Dept Med Vet, Lab Oncol Comparada & Translac, Pirassununga, SP - Brazil
[2] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, Sao Paulo, SP - Brazil
[3] Odontovet Ctr Odontol Vet, Sao Paulo, SP - Brazil
[4] Onco Cane Vet, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Comparative Pathology; v. 173, p. 49-57, NOV 2019.
Web of Science Citations: 0
Abstract

Malignant melanomas (MMs) represent 7% of all malignant neoplasms in dogs. Oral melanocytic neoplasms are often malignant and associated with poor prognosis. There are no universally accepted prognostic markers for canine oral melanoma. Galectin (Gal)-3 is a prognostic marker for human neoplasms such as thyroid, gastric, colorectal and prostate cancers. The protein is related to processes that favour cancer progression, such as angiogenesis, proliferation and apoptosis. The aim of the present study was to characterize the immunohistochemical expression of Gal-3 in canine oral melanomas and to compare it with post-surgical survival, the expression of apoptosis-related proteins and other known prognostic tools. Twenty-seven samples of canine oral melanomas were evaluated for Gal-3, B-cell lymphoma (BCL) 2, caspase (CASE) 3 and Ki67 expression, mitotic index and degree of nuclear atypia. Gal-3 cytoplasmic positivity was correlated positively, while nuclear positivity was correlated negatively, with survival. The intensity of BCL2 labelling was also correlated positively with Gal-3 cytoplasmic positivity. Higher nuclear atypia was observed in dogs with melanoma that died due to the tumour, as well as in dogs that survived for <1 year after surgery. We have confirmed the importance of nuclear atypia for MMs and suggest that Gal-3 is a valuable prognostic indicator for this neoplasm. More in-depth studies are needed to unveil Gal-3 functions in canine MMs using larger sample sizes. (C) 2019 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/13252-8 - Characterization of apoptosis related genes in canine cutaneous mast cell tumors and its value as prognostic indicators
Grantee:Ricardo de Francisco Strefezzi
Support Opportunities: Regular Research Grants
FAPESP's process: 15/11959-2 - Immunohistochemical characterization of galectin-3 as a prognostic tool in canine oral melanomas
Grantee:Thiago Henrique Moroni Vargas
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 16/03862-1 - Characterization of cancer associated fibroblasts and its influence on canine neoplasms
Grantee:Ricardo de Francisco Strefezzi
Support Opportunities: Regular Research Grants