Self-sustained activity of low firing rate in balanced networks

Author(s):Show less -

Borges, F. S. ^[1] ; Protachevicz, P. R. ^[2] ; Pena, R. F. O. ^[3] ; Lameu, E. L. ^{[4, 5]} ; Higa, V, G. S. ; Kihara, J. A. H. ^[6] ; Matias, F. S. ^{[7, 8]} ; Antonopoulos, C. G. ^[9] ; de Pasquale, R. ^[10] ; Roque, A. C. ^[3] ; Iarosz, K. C. ^[11] ; Ji, P. ^{[12, 13]} ; Batista, A. M. ^{[14, 2]}

Affiliation:Show less -

^[1] Fed Univ ABC, Ctr Math Computat & Cognit, Sao Bernardo Do Campo, SP - Brazil

^[2] Univ Estadual Ponta Grossa, Grad Sci Program Phys, Ponta Grossa, PR - Brazil

^[3] Univ Sao Paulo, Dept Phys, Lab Neural Syst, Ribeirao Preto, SP - Brazil

^[4] Humboldt Univ, Dept Phys, Berlin - Germany

^[5] Natl Inst Space Res, Sao Jose Dos Campos, SP - Brazil

^[6] Higa, G. S., V, Fed Univ ABC, Ctr Math Computat & Cognit, Sao Bernardo Do Campo, SP - Brazil

^[7] Univ Fed Alagoas, Inst Phys, Maceio, Alagoas - Brazil

^[8] Univ Paris Saclay, Univ Paris Sud, Cognit Neuroimaging Unit, CEA DRF I2BM, INSERM, F-91191 Gif Sur Yvette - France

^[9] Univ Essex, Dept Math Sci, Wivenhoe Pk, Colchester, Essex - England

^[10] Univ Sao Paulo, Dept Physiol & Biophys, ICB, Sao Paulo, SP - Brazil

^[11] Univ Sao Paulo, Inst Phys, Sao Paulo, SP - Brazil

^[12] Fudan Univ, Minist Educ, Key Lab Computat Neurosci & Brain Inspired Intell, Shanghai - Peoples R China

^[13] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai - Peoples R China

^[14] Univ Estadual Ponta Grossa, Dept Math & Stat, Ponta Grossa, PR - Brazil

• Document type: Journal article
• Source: PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS; v. 537, JAN 1 2020.
• Web of Science Citations: 0

Abstract

Self-sustained activity in the brain is observed in the absence of external stimuli and contributes to signal propagation, neural coding, and dynamic stability. It also plays an important role in cognitive processes. In this work, by means of studying intracellular recordings from CA1 neurons in rats and results from numerical simulations, we demonstrate that self-sustained activity presents high variability of patterns, such as low neural firing rates and activity in the form of small-bursts in distinct neurons. In our numerical simulations, we consider random networks composed of coupled, adaptive exponential integrate-and-fire neurons. The neural dynamics in the random networks simulates regular spiking (excitatory) and fast spiking (inhibitory) neurons. We show that both the connection probability and network size are fundamental properties that give rise to self-sustained activity in qualitative agreement with our experimental results. Finally, we provide a more detailed description of self-sustained activity in terms of lifetime distributions, synaptic conductances, and synaptic currents. (C) 2019 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 16/23398-8 - Synaptic plasticity in neuronal networks with time delay
• Grantee: Ewandson Luiz Lameu
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/07699-0 - Research, Innovation and Dissemination Center for Neuromathematics - NeuroMat
• Grantee: Oswaldo Baffa Filho
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• FAPESP's process: 15/50122-0 - Dynamic phenomena in complex networks: basics and applications
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• FAPESP's process: 17/18977-1 - Analysis of Electrical Synapses Contribution in Neuronal Synchronization
• Grantee: Fernando da Silva Borges
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 15/07311-7 - Dynamic behaviour of neural networks
• Grantee: Kelly Cristiane Iarosz
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 11/19296-1 - Nonlinear dynamics
• Grantee: Iberê Luiz Caldas
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/13502-5 - Synchronisation in time-delayed networks with synaptic plasticity
• Grantee: Ewandson Luiz Lameu
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• FAPESP's process: 17/20920-8 - Plasticity in neuronal networks
• Grantee: Kelly Cristiane Iarosz
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 17/26439-0 - An interdisciplnary approach on the role of gap junctions and miRNAs in the development and degeneration of the nervous system
• Grantee: Alexandre Hiroaki Kihara
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/25667-8 - Mechanisms of propagation of epileptiform activity in a large-scale cortical model
• Grantee: Rodrigo Felipe de Oliveira Pena
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)