| Full text | |
| Author(s): Show less - |
Diniz, Giovanne B.
[1]
;
Battagello, Daniella S.
[1, 2]
;
Cherubini, Pedro M.
[1]
;
Reyes-Mendoza, Julio D.
[2]
;
Luna-Illades, Cesar
[2]
;
Klein, Marianne O.
[1]
;
Motta-Teixeira, Livia C.
[3, 1]
;
Sita, Luciane V.
[1]
;
Miranda-Anaya, Manuel
[4]
;
Morales, Teresa
[2]
;
Bittencourt, Jackson C.
[1, 5]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, SP - Brazil
[2] Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Celular & Mol, Santiago De Queretaro, Queretaro - Mexico
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, SP - Brazil
[4] Univ Nacl Autonoma Mexico, Fac Ciencias, Unidad Multidisciplinaria Docencia Invest, Santiago De Queretaro, Queretaro - Mexico
[5] Univ Sao Paulo, Inst Psychol, Ctr Neurosci & Behav, Sao Paulo, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | JOURNAL OF COMPARATIVE NEUROLOGY; v. 527, n. 18, p. 2973-3001, DEC 15 2019. |
| Web of Science Citations: | 2 |
| Abstract | |
Melanin-concentrating hormone (MCH) is a conserved neuropeptide, predominantly located in the diencephalon of vertebrates, and associated with a wide range of functions. While functional studies have focused on the use of the traditional mouse laboratory model, critical gaps exist in our understanding of the morphology of the MCH system in this species. Even less is known about the nontraditional animal model Neotomodon alstoni (Mexican volcano mouse). A comparative morphological study among these rodents may, therefore, contribute to a better understanding of the evolution of the MCH peptidergic system. To this end, we employed diverse immunohistochemical protocols to identify key aspects of the MCH system, including its spatial relationship to another neurochemical population of the tuberal hypothalamus, the orexins. Three-dimensional (3D) reconstructions were also employed to convey a better sense of spatial distribution to these neurons. Our results show that the distribution of MCH neurons in all rodents studied follows a basic plan, but individual characteristics are found for each species, such as the preeminence of a periventricular group only in the rat, the lack of posterior groups in the mouse, and the extensive presence of MCH neurons in the anterior hypothalamic area of Neotomodon. Taken together, these data suggest a strong anatomical substrate for previously described functions of the MCH system, and that particular neurochemical and morphological features may have been determinant to species-specific phenotypes in rodent evolution. (AU) | |
| FAPESP's process: | 16/02224-1 - The existence of neurogenesis during the lactation period |
| Grantee: | Jackson Cioni Bittencourt |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/02748-0 - Study of the anatomical basis for a volume transmission mechanism on the Melanin Concentrating Hormone [MCH] peptidergic system |
| Grantee: | Giovanne Baroni Diniz |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 14/22313-3 - Influence of the absence of maternal melatonin during pregnancy and lactation on neurogenesis and on somatic and sensorimotor development of the offspring. |
| Grantee: | Lívia Clemente Motta Teixeira |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/17998-5 - Evaluating chronic administration of melanin concentrating hormone (MCH) effects in lactating Long-Evans rats |
| Grantee: | Marianne Orlandini Klein |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/18941-4 - Effects of maternal melatonin deprivation during pregnancy and lactation on the offspring neuroimmune system |
| Grantee: | Lívia Clemente Motta Teixeira |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 17/16293-8 - The existence of neurogenesis during the lactation period - multiuser equipment approved in Fapesp Grant number 2016/02224-1: confocal microscope, brand Zeiss, model LSM 800 |
| Grantee: | Jackson Cioni Bittencourt |
| Support Opportunities: | Multi-user Equipment Program |