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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Designing Silver Nanoparticles for Detecting Levodopa (3,4-Dihydroxyphenylalanine, L-Dopa) Using Surface-Enhanced Raman Scattering (SERS)

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Author(s):
Goncalves Rubira, Rafael Jesus [1] ; Camacho, Sabrina Alessio [2] ; Martin, Cibely Silva [1] ; Mejia-Salazar, Jorge Ricardo [3] ; Reyes Gomez, Faustino [4] ; da Silva, Robson Rosa [4] ; de Oliveira Junior, Osvaldo Novais [4] ; Alessio, Priscila [1] ; Leopoldo Constantino, Carlos Jose [1]
Total Authors: 9
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Technol & Appl Sci, BR-19060900 Presidente Prudente, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Sci Humanities & Languages, BR-19806900 Assis, SP - Brazil
[3] Natl Inst Telecommun Inatel, BR-37540000 Santa Rita Do Sapucai, MG - Brazil
[4] Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: SENSORS; v. 20, n. 1 JAN 2020.
Web of Science Citations: 9
Abstract

Detection of the drug Levodopa (3,4-dihydroxyphenylalanine, L-Dopa) is essential for the medical treatment of several neural disorders, including Parkinson's disease. In this paper, we employed surface-enhanced Raman scattering (SERS) with three shapes of silver nanoparticles (nanostars, AgNS; nanospheres, AgNP; and nanoplates, AgNPL) to detect L-Dopa in the nanoparticle dispersions. The sensitivity of the L-Dopa SERS signal depended on both nanoparticle shape and L-Dopa concentration. The adsorption mechanisms of L-Dopa on the nanoparticles inferred from a detailed analysis of the Raman spectra allowed us to determine the chemical groups involved. For instance, at concentrations below/equivalent to the limit found in human plasma (between 10(-7)-10(-8) mol/L), L-Dopa adsorbs on AgNP through its ring, while at 10(-5)-10(-6) mol/L adsorption is driven by the amino group. At even higher concentrations, above 10(-4) mol/L, L-Dopa polymerization predominates. Therefore, our results show that adsorption depends on both the type of Ag nanoparticles (shape and chemical groups surrounding the Ag surface) and the L-Dopa concentration. The overall strategy based on SERS is a step forward to the design of nanostructures to detect analytes of clinical interest with high specificity and at varied concentration ranges. (AU)

FAPESP's process: 13/14262-7 - Nanostructured films from biologically-relevant materials
Grantee:Osvaldo Novais de Oliveira Junior
Support Opportunities: Research Projects - Thematic Grants