Controlled drug delivery system by fs-laser micromachined biocompatible rubber latex membranes

Author(s)

Almeida, G. F. B. ^{[1, 2]} ; Cardoso, M. R. ^[2] ; Zancanela, D. C. ^[3] ; Bernardes, L. L. ^[4] ; Norberto, A. M. Q. ^[5] ; Barros, N. R. ^{[6, 3]} ; Paulino, C. G. ^[6] ; Chagas, A. L. D. ^[6] ; Herculano, R. D. ^[6] ; Mendonca, C. R. ^[2]

Affiliation

^[1] Univ Fed Uberlandia, Inst Phys, POB 593, BR-38400902 Uberlandia, MG - Brazil

^[2] Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13561970 Sao Carlos, SP - Brazil

^[3] Sao Paulo State Univ, Chem Inst, BR-14800900 Araraquara, SP - Brazil

^[4] Sao Paulo State Univ, Sch Sci & Letters, BR-19806900 Assis, SP - Brazil

^[5] Univ Sao Paulo, Fac Med, BR-14040900 Ribeirao Preto, SP - Brazil

^[6] Sao Paulo State Univ, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP - Brazil

• Document type: Journal article
• Source: Applied Surface Science; v. 506, MAR 15 2020.
• Web of Science Citations: 0

Abstract

The concept behind drug delivery systems is to provide the correct amount of pharmaceutical compound to a desired body part within a predefined timespan. It can be made of various materials such as liposomes, niosomes, nano/microcapsules, cyclodextrins, polymers and many more. Natural rubber latex is used as solid matrix for drug delivery because it stimulates the healing process of wounds and angiogenesis. In this context, we have produced natural rubber latex membranes with of 2000, 6000 and 10,000 pore/cm(2) via fs-laser micromachining and studied its influence on the drug delivery experiments. Drug release kinetics of Ciprofloxacin-loaded microdrilled biopolymer samples showed that the final concentration of drug released has a linear dependence with the pore density. According to infrared spectroscopy analysis, latex membranes maintained their structural properties after ultrashort pulse irradiation and ciprofloxacin adsorption. The demonstration of a fast and reliable production of a controlled drug delivery system puts fs-laser micromachined porous natural rubber latex as a promising candidate for in vivo application in which a proper amount of drug needs to be released. (AU)

• FAPESP's process: 13/18307-5 - Evaluation of ciprofloxacin controlled release using natural rubber latex membranes micromachined by femtosecond laser pulses
• Grantee: Letícia Leite Bernardes
• Support type: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 11/17411-8 - Evaluation of drugs delivery systems using natural rubber latex membranes as carrier
• Grantee: Rondinelli Donizetti Herculano
• Support type: Regular Research Grants
• FAPESP's process: 18/11283-7 - Nonlinear photonics: spectroscopy and advanced processing of materials
• Grantee: Cleber Renato Mendonça
• Support type: Research Projects - Thematic Grants