Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt/mTOR/S6K Signaling Pathway

Author(s)

Chaves, Fernanda Machado ^{[1, 2]} ; Betim Pavan, Isadora Carolina ^{[3, 1]} ; Salvino da Silva, Luiz Guilherme ^[1] ; de Freitas, Lidia Broglio ^[3] ; Rostagno, Mauricio Ariel ^[1] ; Costa Antunes, Adriane Elisabete ^[2] ; Neves Bezerra, Rosangela Maria ^[1] ; Simabuco, Fernando Moreira ^{[3, 1]}

Affiliation

^[1] Univ Campinas UNICAMP, Sch Appl Sci FCA, Multidisciplinary Lab Food & Hlth LABMAS, R Pedro Zaccaria 1300, BR-13484350 Limeira, SP - Brazil

^[2] Univ Campinas UNICAMP, Sch Appl Sci FCA, Dairy Probiot & Prebiot Lab LLPP, Limeira, SP - Brazil

^[3] Univ Campinas UNICAMP, Sch Appl Sci FCA, Lab Metab Disorders LABDIME, Limeira, SP - Brazil

• Document type: Journal article
• Source: PLANT FOODS FOR HUMAN NUTRITION; v. 75, n. 1, p. 54-62, MAR 2020.
• Web of Science Citations: 0

Abstract

Pomegranate (Punica granatum) is known to contain polyphenols with many potential health benefits, including anti-tumoral, anti-inflammatory, and anti-microbial properties. It has been used in popular medicine for cancer treatment, which still represents the major cause of cancer-related deaths in men worldwide. Importantly, pomegranate peels are valuable by-products of the food industry that are rich in polyphenols. Here we report a comparison between juice and peel aqueous extracts in prostate cancer DU-145 and PC-3 cell lines. Both extracts were able to inhibit the proliferation, migration and colony formation of those cells, although peel extracts presented more robust effects compared to juice. Besides, the growth-related mTOR/S6K signaling pathway presented strong inhibition after pomegranate extracts treatment. This study presents evidence that both juice and isolated peel extracts from promegate fruit have important anti-cancer effects against prostate cancer cells, modulating the mTOR/S6K signaling pathway. (AU)

• FAPESP's process: 15/07299-7 - Evaluation of a new sport drink containing probiotic, pomegranate pulp (Punica granatum L.) and whey protein isolated and this effect on performance, immune response and microbiota
• Grantee: Adriane Elisabete Antunes de Moraes
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/14818-9 - Study of molecular targets important for the control of cancer metabolism: the mTOR/S6K pathway as a central role
• Grantee: Fernando Moreira Simabuco
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 16/06457-0 - Leaves and stalks of beet (Beta vulgaris L.): characterization and effects of the antioxidant capacity in obese and dyslipidemic
• Grantee: Rosângela Maria Neves Bezerra
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/13558-7 - Molecular characterization of S6Ks in obesity and its associated diseases
• Grantee: Fernando Moreira Simabuco
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 13/04304-4 - Development of integrated systems for the analysis of bioactive compounds in natural products employing supercritical technology
• Grantee: Maurício Ariel Rostagno
• Support Opportunities: Research Grants - Young Investigators Grants