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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A comparison between electrospinning and rotary-jet spinning to produce PCL fibers with low bacteria colonization

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Author(s):
Machado-Paula, M. M. [1, 2] ; Corat, M. A. F. [3] ; Lancellotti, M. [4] ; Mi, G. [1] ; Marciano, F. R. [5, 1] ; Vega, M. L. [6] ; Hidalgo, A. A. [6] ; Webster, T. J. [1] ; Lobo, A. O. [7, 1]
Total Authors: 9
Affiliation:
[1] Northeastern Univ, Dept Chem Engn, Nanomed Labs, Boston, MA 02115 - USA
[2] Univ Vale Paraiba, Programa Posgrad Engn Biomed, BR-12244000 Sao Jose Dos Campos, SP - Brazil
[3] Univ Estadual Campinas, Multidisciplinary Ctr Biol Res, BR-13083877 Campinas, SP - Brazil
[4] Univ Estadual Campinas, Fac Pharmaceut Sci, Lab Biotechnol, BR-13083877 Campinas, SP - Brazil
[5] UFPI Fed Univ Piaui, Dept Phys, BR-64049550 Teresina, PI - Brazil
[6] UFPI Fed Univ Piaui, Dept Phys, Mat & Bionanotechnol Lab, BR-64049550 Teresina, PI - Brazil
[7] UFPI Fed Univ Piaui, Dept Mat Engn, LIMAV Interdisciplinary Lab Adv Mat, BR-64049550 Teresina, PI - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Materials Science & Engineering C-Materials for Biological Applications; v. 111, JUN 2020.
Web of Science Citations: 0
Abstract

One of the important components in tissue engineering is material structure, providing a model for fixing and the development of cells and tissues, which allows for the transport of nutrients and regulatory molecules to and from cells. The community claims the need for new materials with better properties for use in the clinic. Poly (epsilon-caprolactone) (PCL) is a biodegradable polymer, semi crystalline, with superior mechanical properties and has attracted an increasing interest due to its usefulness in various biomedical applications. Herein, two different methods (electrospinning versus rotary jet spinning) with different concentrations of PCL produced ultra thinfibers each with particular characteristics, verified and analyzed by morphology, wettability, thermal and cytotoxicity features and for bacteria colonization. Different PCL scaffold morphologies were found to be dependent on the fabrication method used. All PCL scaffolds showed greater mammalian cell interactions. Most impressively, rotary-jet spun fibers showed that a special rough surface decreased bacteria colonization, emphasizing that no nanoparticle or antibiotic was used; maybe this effect is related with physical (scaffold) and/or biological mechanisms. Thus, this study showed that rotary jet spun fibers possess a special topography compared to electrospun fibers to reduce bacteria colonization and present no cytotoxicity when in contact with mammalian cells. (AU)

FAPESP's process: 11/20345-7 - Study of nanoparticle-incorporated diamond-like carbon films for biomedical applications
Grantee:Fernanda Roberta Marciano
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/08523-8 - Development of a fluorescent nanosensor from the electrospinning of PVA and graphene quantum dots: application in the detection of Alzheimer's biomarkers
Grantee:Bruno Vinícius Manzolli Rodrigues
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/17877-7 - Development of new polymeric scaffolds by electrospinning technique with incorporation of vertically aligned carbon nanotubes and nanohidroxyapatite for bone tissue regeneration
Grantee:Anderson de Oliveira Lobo
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 14/50869-6 - INCT 2014: on Organic Electronics
Grantee:Roberto Mendonça Faria
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/16295-2 - Nanofibers produced by electrospinning and rotary jet-spinning with incorporated hydroxyapatite and carbon nanotubes to verify its potential in bone regeneration
Grantee:Mirian Michelle Machado de Paula
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/09697-0 - Electrospinning of novel functional nanobiomaterials based on peptides and bottlebrush polymers for tissue engineering
Grantee:Anderson de Oliveira Lobo
Support type: Scholarships abroad - Research