On the stationary frequency of programmed ribosomal-1 frameshift

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Author(s):	Schuetz, G. M. Total Authors: 1
Document type:	Journal article
Source:	JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT; v. 2020, n. 4 APR 2020.
Web of Science Citations:	0
Abstract
We present a stochastic model for programmed ribosomal -1 frameshift, triggered by a slippery sequence and a following pseudoknot on the mRNA template, that allows for the exact derivation of the stationary distribution of ribosome positions and for exact analytical calculations of the stationary rate of frameshift, its efficiency and other quantities of interest. We also present the stationary phase diagram as a function of the initiation rate and the density ribosomes that the pseudoknot can support. These observations provide mathematically rigorous evidence for the notion that the density of molecular motors is an important control parameter for the elongation rate in the presence of slippery sequences both in transcription of RNA and translation of proteins. (AU)

FAPESP's process:	17/20696-0 - From interacting particle systems to topological data analysis
Grantee:	Vladimir Belitsky
Support Opportunities:	Research Grants - Visiting Researcher Grant - International


FAPESP's process:	17/10555-0 - Stochastic modeling of interacting systems
Grantee:	Fabio Prates Machado
Support Opportunities:	Research Projects - Thematic Grants