Loss of Brain-Derived Neurotrophic Factor Mediates Inhibition of Hippocampal Long-Term Potentiation by High-Intensity Sound

Author(s)

de Deus, Junia L. ^{[1, 2]} ; Amorim, Mateus R. ^[2] ; Ribeiro, Aline B. ^[1] ; Barcellos-Filho, Procopio C. G. ^[1] ; Ceballos, Cesar C. ^[1] ; Branco, Luiz Guilherme S. ^[1] ; Cunha, Alexandra O. S. ^[2] ; Leao, Ricardo M. ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dent Sch Ribeirao Preto, Dept Basic & Oral Biol, BR-14040904 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: Cellular and Molecular Neurobiology; v. 41, n. 4 MAY 2020.
• Web of Science Citations: 0

Abstract

Exposure to noise produces cognitive and emotional disorders, and recent studies have shown that auditory stimulation or deprivation affects hippocampal function. Previously, we showed that exposure to high-intensity sound (110 dB, 1 min) strongly inhibits Schaffer-CA1 long-term potentiation (LTP). Here we investigated possible mechanisms involved in this effect. We found that exposure to 110 dB sound activates c-fos expression in hippocampal CA1 and CA3 neurons. Although sound stimulation did not affect glutamatergic or GABAergic neurotransmission in CA1, it did depress the level of brain-derived neurotrophic factor (BDNF), which is involved in promoting hippocampal synaptic plasticity. Moreover, perfusion of slices with BDNF rescued LTP in animals exposed to sound stimulation, whereas BDNF did not affect LTP in sham-stimulated rats. Furthermore, LM22A4, a TrkB receptor agonist, also rescued LTP from sound-stimulated animals. Our results indicate that depression of hippocampal BDNF mediates the inhibition of LTP produced by high-intensity sound stimulation. (AU)

• FAPESP's process: 16/17681-9 - Pathophysiological changes during systemic inflammation
• Grantee: Luiz Guilherme de Siqueira Branco
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/22327-7 - Analysis of electrophysiological and morphofunctional properties of neurons in the central nucleus of inferior colliculus related to genesis and spreading of sound-induced convulsive seizures
• Grantee: Alexandra Olimpio Siqueira Cunha
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 16/01607-4 - High intensity sound stimulation and synaptic plasticity
• Grantee: Ricardo Mauricio Xavier Leão
• Support Opportunities: Regular Research Grants