Exposure to per- and polyfluorinated alkyl substances in pregnant Brazilian women and its association with fetal growth

Author(s)

Oliveira Souza, Marilia Cristina ^{[1, 2, 3]} ; Saraiva, Maria Conceicao Pereira ^[4] ; Honda, Masato ^{[1, 3, 5]} ; Barbieri, Marco Antonio ^[6] ; Bettiol, Heloisa ^[6] ; Barbosa, Fernando ^[2] ; Kannan, Kurunthachalam ^{[1, 7, 3]}

Affiliation

^[1] NYU, Dept Environm Med, Sch Med, New York, NY 10016 - USA

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Lab Toxicol Analit & Sistemas, BR-14040903 Ribeirao Preto, SP - Brazil

^[3] NYU, Dept Pediat, Sch Med, New York, NY 10016 - USA

^[4] Univ Sao Paulo, Fac Odontol Ribeirao Preto, Dept Clin Infantil, BR-14040904 Ribeirao Preto, SP - Brazil

^[5] Kanazawa Univ, Inst Nat & Environm Technol, Kanazawa, Ishikawa 920119 - Japan

^[6] Univ Sao Paulo, Dept Puericultura & Pediat, Fac Med Ribeirao Preto, Sao Paulo - Brazil

^[7] King Abdulaziz Univ, Fac Sci, Biochem Dept, Jeddah - Saudi Arabia

• Document type: Journal article
• Source: Environmental Research; v. 187, AUG 2020.
• Web of Science Citations: 0

Abstract

Research pertaining to exposure of humans to per- and polyfluorinated alkyl substances (PFASs) has received considerable public and regulatory attention in recent years. Although several studies have reported exposure to PFASs by populations in North America and western Europe, such information is still scarce in Latin America, including Brazil. In this study, concentrations of thirteen PFASs were determined in whole blood collected during the second trimester from 252 pregnant Brazilian women. This is a nested case-control study within the Brazilian Ribeirao Preto and Sao Luiz Birth Cohort Study (BRISA) with selected birth outcomes cases (n = 63) and matched controls (n = 189). PFASs concentrations were associated with conditions including preeclampsia, birth weight (BW), preterm birth, and intrauterine growth restriction (IUGR). Among PFASs measured, per- fluorooctane sulfonate (PFOS) was found at the highest concentration (range: 1.06-106 ng(-1) with a median value of 3.41 ng mL(-1)) which was followed by perfluorooctanoic acid (PFOA, range: 0.11-2.77 ng mL(-1) with a median value of 0.20 ng mL(-1)). A significant positive association of PFOS and PFOA concentrations with fetal growth restriction (p < 0.05) was found. This is the first study to assess whole blood concentrations of PFASs and their effect on fetal growth in pregnant Brazilian women. (AU)

• FAPESP's process: 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health
• Grantee: Fernando Barbosa Júnior
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/23372-9 - Exposure of Brazilian pregnant women to perfluorinated compounds in blood: levels and correlations with potential health implications.
• Grantee: Marília Cristina Oliveira Souza
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 15/19665-8 - Determination of the main representatives of polybrominated diphenyl ethers class (PBDEs) in fish, eggs and milk employing microextraction packed sorbent (MEPS) and gas chromatography coupled with mass spectrometry (GC-MS)
• Grantee: Marília Cristina Oliveira Souza
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 08/53593-0 - Etiological factors of preterm birth and consequences of perinatal factors in child health: birth cohorts in two Brazilian cities (BRISA project)
• Grantee: Marco Antonio Barbieri
• Support Opportunities: Research Projects - Thematic Grants