Effects of the jucara fruit supplementation on metabolic parameters in individuals with obesity: a double-blind randomized controlled trial

Author(s)

Jamar, Giovana ^{[1, 2]} ; Santamarina, Aline Boveto ^{[1, 2]} ; Flygare, Ana Carolina ^[1] ; Gagliardi, Antonio ^[3] ; de Rosso, Veridiana Vera ^[4] ; Dourado, Victor Zuniga ^[5] ; Pisani, Luciana Pellegrini ^{[4, 2]}

Affiliation

^[1] Univ Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, Santos, SP - Brazil

^[2] Univ Fed Sao Paulo, Lab Nutr & Fisiol Endocrina LaNFE, Santos, SP - Brazil

^[3] Angiocorpore Inst Med Cardiovasc, Dept Med Cardiovasc, Santos, SP - Brazil

^[4] Univ Fed Sao Paulo, Inst Saude & Soc, Dept Biociencias, Santos, SP - Brazil

^[5] Univ Fed Sao Paulo, Dept Ciencias Movimento Humano, Santos, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 83, SEP 2020.
• Web of Science Citations: 0

Abstract

Adipose tissue inflammation has been proposed as a central mechanism connecting obesity with its metabolic and vascular complications due to the imbalance in the expression of several hormones and adipokines. Berries rich in polyphenols and unsaturated fatty acids have been able to prevent both obesity and adipose tissue inflammation, improving metabolic functions in human subjects and animal models of obesity. Jucara has been considered a super fruit owing to its nutritional composition and relevant biological activities with an interesting response in animals. Thus, we aimed to verify the potential antiobesogenic effect of jucara supplementation in humans. We conducted a double-blind, placebo-controlled, randomized trial with 35 adults with obesity of both sexes. They were assessed for resting metabolic rate, anthropometry and body composition, blood pressure, metabolic parameters and adipokines. Subsequently, they were randomized into two groups to use or not (placebo) 5 g lyophilized jucara for 6 weeks. Supplementation with jucara was significantly effective in reducing body fat, increasing high-density lipoprotein cholesterol and doubling serum adiponectin. Besides, jucara supplementation, high-density lipoprotein cholesterol and neck circumference were predictors to explain the enhancement in adiponectin. Jucara supplementation was determinant to improve adiponectin levels, and it may be considered a novel strategy for the treatment of obesity-related metabolic diseases. (C) 2020 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 16/14133-0 - Intracellular mechanisms implicated to inflammatory process in obese subjects before and after supplementation juçara pulp
• Grantee: Luciana Pellegrini Pisani
• Support Opportunities: Regular Research Grants