In situ effect of a proanthocyanidin mouthrinse on dentin subjected to erosion

Author(s)

Fabrícia CARDOSO ^[1] ; Ana Paula BOTEON ^[2] ; Tamires Alves Pereira da SILVA ^[3] ; Anuradha PRAKKI ^[4] ; Linda WANG ^[5] ; Heitor Marques HONÓRIO ^[6]

Affiliation

^[1] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Dentística, Endodontia e Materiais Odontológicos - Brasil

^[2] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Dentística, Endodontia e Materiais Odontológicos - Brasil

^[3] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Odontopediatria, Ortodontia e Saúde Coletiva - Brasil

^[4] University of Toronto. Faculty of Dentistry. Department of Clinical Sciences (Restorative) - Canadá

^[5] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Dentística, Endodontia e Materiais Odontológicos - Brasil

^[6] Universidade de São Paulo. Faculdade de Odontologia de Bauru. Departamento de Odontopediatria, Ortodontia e Saúde Coletiva - Brasil

• Document type: Journal article
• Source: Journal of Applied Oral Science; v. 28, 2020-10-23.

Abstract

Abstract Proanthocyanidin has been shown to be efficient in inhibiting matrix metalloproteinases. Objective The aim of this in situ study was to evaluate the protective effect of Proanthocyanidin-based mouthrinses either with naturally acidic or with a neutral pH applied on dentin subjected to erosion. Methodology Eight volunteers wore one palatal device in two phases (7 days washout) with 16 samples per group (n=8). The groups under study were: First Phase/ G1 – 10% proanthocyanidin mouthrinse (pH 7.0, Experimental group 1 – Purified Grape Seeds Oligomeric Proanthocyanidins), G2 – 10% proanthocyanidin mouthrinse (pH 3.0, Experimental group 2 – Purified Grape Seeds Oligomeric Proanthocyanidins). Second Phase/ G3 – 0.12% chlorhexidine mouthrinse (pH 7.0, Positive control group), G4 – no previous treatment (Negative control group). Each device was subjected to 3 erosive cycles (5 minutes) per day for 5 days. Treatments with different mouthrinses were applied once after the second erosive challenge (5 minutes). Profilometry was used to quantify dentin loss (µm). Results Data were analyzed by repeated measures of ANOVA followed by Fisher’s test (p<0.05). G1 (1.17±0.69) and G3 (1.22±0.25) showed significantly lower wear values with no statistical difference between them. G2 (2.99±1.15) and G4 (2.29±1.13) presented higher wear values with no significant differences between them. Conclusion The 10% proanthocyanidin mouthrinse (pH 7.0) could be a good strategy to reduce dentin wear progression. (AU)

• FAPESP's process: 18/05847-5 - Effect of metalloproteinases inhibitors and/or remineralizing agents on tooth structure submitted to erosion
• Grantee: Heitor Marques Honório
• Support Opportunities: Regular Research Grants