| Full text | |
| Author(s): Show less - |
El-Mafarjeh, Elias
[1, 2]
;
Martins, Gisele Henrique Cardoso
[3]
;
Probst, Jessica Jorge
[3]
;
Santos-Dias, Alana
[2]
;
Oliveira-Junior, Manoel Carneiro
[2]
;
de Barros, Marcelo Paes
[4]
;
de Oliveira, Luis Vicente Franco
[5]
;
de Andrade, Leandro Damas
[5]
;
da Palma, Renata Kelly
[6, 7]
;
Moraes-Ferreira, Renilson
[8]
;
de Camargo Hizume-Kunzler, Deborah
[3]
;
Bachi, Andre Luis Lacerda
[2, 9, 10]
;
Vieira, Rodolfo P.
[7, 8, 2, 11]
Total Authors: 13
|
| Affiliation: Show less - | [1] Sirio Libanes Hosp, Dept Paediat, Ave Brasil 915, BR-01431000 Sao Paulo, SP - Brazil
[2] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Rua Pedro Ernesto 240, BR-12245520 Sao Jose Dos Campos SP, SP - Brazil
[3] Univ State Santa Catarina UDESC, Dept Phys Therapy LaPEx, Ave Madre Benvenuta 2007, BR-88035901 Florianopolis, SC - Brazil
[4] Univ Cruzeiro Sul, Inst Phys Act Sci & Sports, Interdisciplinary Postgrad Program Hlth Sci, Rua Galvao Bueno 868, BR-01506000 Sao Paulo, SP - Brazil
[5] Ctr Univ UniEvangel, Postgrad Program Human Movement & Rehabil, Ave Univ Km 3, 5, BR-75083515 Anapolis, Go - Brazil
[6] Univ Sao Paulo, Dept Surg, Sch Vet Med & Anim Sci, Sao Paulo - Brazil
[7] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, Rua Carolina Fonseca 235, BR-08230030 Sao Paulo, SP - Brazil
[8] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Ave Ana Costa 95, BR-11060001 Santos, SP - Brazil
[9] Fed Univ Sao Paulo UNIFESP, Dept Otorrhynolaryngol, Rua Pedro de Toledo, 950 Vila Clementino, BR-04038002 Sao Paulo, SP - Brazil
[10] Univ Santo Amaro, Postgrad Program Hlth Sci, Rua Isabel Schmidt, 349 Santo Amaro, BR-04743030 Sao Paulo, SP - Brazil
[11] Biomimet Syst Cell Engn IBEC, Inst Bioengn Catalonia, C Baldiri Reixac 15-21, Barcelona 08028 - Spain
Total Affiliations: 11
|
| Document type: | Journal article |
| Source: | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY; v. 2020, OCT 17 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Introduction. Moderate aerobic exercise training accelerates the resolution of lung fibrosis in a model of bleomycin-induced pulmonary fibrosis. However, whether it can inhibit the development of lung fibrosis is unknown. Materials and Methods. C57Bl/6 mice were distributed into four groups: Control (Co), Exercise (Exe), Bleomycin (Bleo), and Bleomycin+Exercise (Bleo+Exe). A single bleomycin dose (1.5 UI/kg) was administered orotracheally and treadmill exercise started in the same day, enduring for 4 weeks, 5x/week, 60 minutes/session, at moderate intensity. Lung mechanics, systemic and pulmonary inflammation, and lung remodeling were evaluated. Lung homogenates were used to evaluate the antioxidant status. Results. Total cells, macrophages, lymphocytes, and neutrophils numbers, in agreement with IL-6 levels, were higher in the BAL and serum of Bleo group, compared to other groups. In addition, lung levels of LTB4 in Bleo were higher than other groups, whereas SOD activity and nitric oxide levels in exercised groups (Exe and Exe+Bleo) compared to the Bleo group. Lung GPX activity was lower in Bleo and Exe+Bleo groups compared to others. Exe and Exe+Bleo groups also showed higher IL-10 expression by lung macrophages than other groups, whereas TGF-beta expression was higher in Exe, Bleo, and Exe+Bleo groups compared to control. CCR7 expression was induced only in the Exe group. However, exercise did not improve lung remodeling and mechanics, or serum and pulmonary levels of VEGF, IGF-1, and TGF-beta. Conclusion. Aerobic exercise training initiated concomitantly with induction of pulmonary fibrosis reduces lung and systemic inflammation but fails to inhibit lung fibrosis and mechanics impairment. (AU) | |
| FAPESP's process: | 19/14115-0 - Influence of L-glutamine supplementation in the sarcopenia and immune/inflammatory response both systemic and in the respiratory tract of elderly practitioners or not of a regular program of combined physical exercises submitted to Influenza virus vaccine |
| Grantee: | André Luis Lacerda Bachi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/06032-2 - Biochemical, physiological and transcriptomic strategies to study the relationship between carotenoids, oxidative stress and Citrus fruit quality |
| Grantee: | Marcelo Paes de Barros |
| Support Opportunities: | Scholarships abroad - Research |
| FAPESP's process: | 14/14604-8 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in a model of asthma induced by house dust mite |
| Grantee: | Manoel Carneiro de Oliveira Junior |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 16/04845-3 - EFFECT OF DAILY INTAKE OF Lactobacillus casei Shirota (LcS) IN THE SYSTEMIC AND UPPER AIRWAYS IMMUNE RESPONSIVENESS OF AMATEUR MARATHON RUNNERS WHO PRESENT UPPER RESEPIRATORY SYMPTOMS |
| Grantee: | André Luis Lacerda Bachi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/51464-4 - Effects of aerobic exercise on pulmonary fibrosis induced by bleomycin |
| Grantee: | Rodolfo de Paula Vieira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/20562-9 - Do the purinergic signaling via bronchial epithelium and leukocytes contributes to anti-inflammatory effects of physical training in a model of asthma? |
| Grantee: | Elias El-Mafarjeh |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals |
| Grantee: | Rodolfo de Paula Vieira |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 19/11008-9 - The role of physical training in the pulmonary pro and anti-fibrotic responses of asthmatic individuals |
| Grantee: | Renilson Moraes Ferreira |
| Support Opportunities: | Scholarships in Brazil - Master |