| Full text | |
| Author(s): Show less - |
Dayane C. Ribeiro
;
Helena M. Russo
[2]
;
Karina Fraige
[3]
;
Maria L. Zeraik
[4]
;
Cláudio R. Nogueira
[5]
;
Patrícia B. da Silva
[6]
;
Ana C. Codo
[7]
;
Giovana M. F. Calixto
[8]
;
Alexandra I. de Medeiros
[9]
;
Marlus Chorilli
[10]
;
Vanderlan S. Bolzani
[11]
Total Authors: 11
|
| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 32, n. 4, p. 786-799, 2021-03-29. |
| Abstract | |
Platonia insignis fruit, popularly known as bacuri, is traditionally used in folk medicine for its anti-inflammatory and antioxidant properties. Therefore, this study determined the chemical composition and biological activities of the bacuri’s shell and seeds extracts, considered residues from its consumption and industrial uses. Four biflavonoids (GB-2a, GB-1a, morelloflavone, and volkensiflavone) were identified in the extracts by high-performance liquid chromatography-diode array detection (HPLC-DAD), liquid chromatography tandem mass spectrometry (LC-MS/MS), and liquid chromatography-solid phase extraction-nuclear magnetic resonance (LC-SPE-NMR) techniques. Morelloflavone was identified as the main compound in the shell ethyl acetate extract, being responsible for the high in vitro antioxidant (50% effective concentration (EC50) ranging from 8.0-10.5 µg mL−1 in different protocols), anti-glycant (80%), and moderate inhibition of nitric oxide (1.56 µg mL−1 for > 90% cell viability) activities. This extract showed promising in vivo anti-inflammatory activity evaluated through the paw edema protocol after its incorporation into a liquid-crystalline drug carrier system, reducing the edema by up to 31%. The results demonstrated the potential of the fruit for the development of drugs of natural origin and corroborated to add economic value to these discarded residues. (AU) | |
| FAPESP's process: | 17/19870-6 - Effect of phagocytosis of infected apoptotic cells during activation of M1/M2 Macrophages |
| Grantee: | Alexandra Ivo de Medeiros |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/50926-0 - INCT 2014: biodiversity and natural products |
| Grantee: | Vanderlan da Silva Bolzani |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |
| FAPESP's process: | 16/16970-7 - Study of the impact of the role of eIF5A in the cell proteomic profile using Saccharomyces cerevisiae as a model |
| Grantee: | Cleslei Fernando Zanelli |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery |
| Grantee: | Glaucius Oliva |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 17/18807-9 - Efferocytosis of Streptococcus pneumoniae infected apoptotic cells impact on m2 macrophages and Th2 lymphocytes reprogramming |
| Grantee: | Ana Campos Codo |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |