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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chitosan-based systems aimed at local application for vaginal infections

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Author(s):
Sousa Araujo, Victor Hugo [1] ; Chaves de Souza, Mauricio Palmeira [1] ; Carvalho, Gabriela Correa [1] ; Duarte, Jonatas Lobato [1] ; Chorilli, Marlus [1]
Total Authors: 5
Affiliation:
[1] Sao Paulo State Univ, Sch Pharmaceut Sci, Araraquara, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Carbohydrate Polymers; v. 261, JUN 1 2021.
Web of Science Citations: 0
Abstract

Vaginal administration is a promising route for the local treatment of infectious vaginal diseases since it can bypass the first-pass metabolism, drug interactions, and adverse effects. However, the commercial products currently available for topical vulvovaginal treatment have low acceptability and do not adequately explore this route. Mucoadhesive systems can optimize the efficacy of drugs administered by this route to increase the retention time of the drug in the vaginal environment. Several polymers are used to develop mucoadhesive systems, among them chitosan, a natural polymer that is highly biocompatible and technologically versatile. Thus, the present review aimed to analyze the studies that used chitosan to develop mucoadhesive systems for the treatment of local vaginal infections. These studies demonstrated that chitosan as a component of mucoadhesive drug delivery systems (DDS) is a promising device for the treatment of vaginal infectious diseases, due to the intrinsic antimicrobial activity of this biopolymer and because it does not interfere with the effectiveness of the drugs used for the treatment. (AU)

FAPESP's process: 19/10261-2 - Evaluation of the potential of nanostructured lipid carriers for co-encapsulation of curcumin and fluconazole dispersed in thermally-responsive hydrogels in the treatment of vulvovaginal candidiasis
Grantee:Victor Hugo Sousa Araujo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/25125-7 - Nanoemulsions containing terpenes as potentials larvicides and repellents against Aedes aegypti (Linnaeus, 1762)
Grantee:Jonatas Lobato Duarte
Support Opportunities: Scholarships in Brazil - Doctorate