Urea to albumin ratio is a predictor of mortality in patients with septic shock

Author(s)

Pereira, Amanda Gomes ^[1] ; Costa, Nara Aline ^[2] ; Gut, Ana Lucia ^[1] ; Azevedo, Paula Schmidt ^[1] ; Tanni, Suzana Erico ^[1] ; Zornoff, Leonardo Antonio Mamede ^[1] ; de Paiva, Sergio Alberto Rupp ^[1] ; Polegato, Bertha Furlan ^[1] ; Minicucci, Marcos Ferreira ^[1]

Affiliation

^[1] UNESP Univ Estadual Paulista, Botucatu Med Sch, Dept Internal Med, Botucatu, SP - Brazil

^[2] Univ Fed Goias, Fac Nutr, UFG, Goiania, Go - Brazil

• Document type: Journal article
• Source: CLINICAL NUTRITION ESPEN; v. 42, p. 361-365, APR 2021.
• Web of Science Citations: 0

Abstract

Background: The purpose of this study was to evaluate urea to albumin ratio (UAR) as predictor of mortality in patients with septic shock. Methods: We included all individuals aged >= 18 years, with the diagnosis of septic shock at Intensive Care Unit (ICU) admission. Laboratorial and clinical data was recorded within the first 24 h of the patient's admission. Serum urea and albumin concentration were used for UAR calculation. All patients were followed during their ICU stay and the mortality rate was recorded. Results: 222 patients were included in the analysis; the mean age was 62.3 +/- 15.1 years and 66% were male. Mortality rate during the ICU stay was 59.9% and the median UAR was 40.7 (24.5-66.1). The UAR was also higher in patients who died in the ICU and was positively correlated with APACHE II, SOFA score and CRP. The ROC ICU mortality development (AUC: 0.617; CI 95%: 0.541-0.693; p: 0.003) at the cutoff of >= 47.25. Furthermore, UAR values were associated with ICU mortality when adjusted by age, sex and APACHE II (OR: 1.011; CI95%:1.000-1.022; p = 0.043) and when adjusted by lactate (OR: 1.014; CI95%:1.003-1.024; p = 0.009). Conclusions: Our data suggest that UAR could play a role as predictor of ICU mortality in patients with septic shock. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 17/21554-5 - Influence of thiamine suplementation in oxidative stress, energetic metabolism and mortality among patients with septic shock
• Grantee: Amanda Gomes Pereira
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 14/17262-0 - Influence of zinc, copper and superoxide dismutase 1 polymorphism on mortality in patients with septic shock
• Grantee: Marcos Ferreira Minicucci
• Support Opportunities: Regular Research Grants