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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Zika Brazilian Cohorts (ZBC) Consortium: Protocol for an Individual Participant Data Meta-Analysis of Congenital Zika Syndrome after Maternal Exposure during Pregnancy

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Author(s):
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Costa Alecrim, Maria das Gracas [1] ; Ramos de Amorim, Melania Maria [2, 3] ; Barreto de Araujo, Thalia Velho [4] ; Brasil, Patricia [5] ; Brickley, Elizabeth B. [6] ; Castilho, Marcia da Costa [1] ; Coelho, Bernadete Perez [7] ; Ledo Alves da Cunha, Antonio Jose [8] ; Duarte, Geraldo [9] ; Estofolete, Cassia Fernanda [10] ; Gurgel, Ricardo Queiroz [11] ; Herrero-Silva, Juliana [12] ; Hofer, Cristina Barroso [8] ; Alves Lopes, Aline Siqueira [11] ; Turchi Martelli, Celina Maria [13] ; de Oliveira Melo, Adriana Suely [2, 14] ; Miranda-Filho, Democrito de Barros [15] ; Montarroyos, Ulisses Ramos [16] ; Moreira, Maria Elisabeth [17] ; Mussi-Pinhata, Marisa Marcia [9] ; de Oliveira, Consuelo Silva [18] ; Passos, Saulo Duarte [19] ; Prata-Barbosa, Arnaldo [20] ; dos Santos, Darci Neves [21] ; Schuler-Faccini, Lavinia [22] ; Moura da Silva, Antonio Augusto [23] ; de Siqueira, Isadora Cristina [24] ; Sousa, Patricia da Silva [25] ; Turchi, Marilia Dalva [26] ; de Alencar Ximenes, Ricardo Arraes [15, 27] ; de Sene Amancio Zara, Ana Laura [26] ; ZBC-Consortium
Total Authors: 32
Affiliation:
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[1] Fundacao Med Trop Doutor Heitor Vieira Dourado, BR-69040000 Manaus, Amazonas - Brazil
[2] Univ Fed Campina Grande, BR-58428830 Campina Grande, Paraiba - Brazil
[3] Inst Med Integral Prof Fernando Figueira IMIP, BR-50070902 Recife, PE - Brazil
[4] Univ Fed Pernambuco, Dept Med Social, BR-50670901 Recife, PE - Brazil
[5] Fundacao Oswaldo Cruz, Inst Nacl Infectol Evandro Chagas, BR-21040360 Rio De Janeiro - Brazil
[6] London Sch Hyg & Trop Med, London WC1E 7HT - England
[7] Univ Fed Pernambuco, Ctr Ciencias Saude, BR-50670901 Recife, PE - Brazil
[8] Univ Fed Rio de Janeiro, Dept Pediat, BR-21941971 Rio De Janeiro - Brazil
[9] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto - Brazil
[10] Fac Med Sao Jose do Rio Preto, BR-15090000 Sao Jose Do Rio Preto - Brazil
[11] Univ Fed Sergipe, BR-49060108 Aracaju - Brazil
[12] Secretaria Municipal Tangara da Serra, BR-78300000 Tangara Da Serra - Brazil
[13] Fundacao Oswaldo Cruz, Inst Aggeu Magalhaes, BR-50740465 Recife, PE - Brazil
[14] Inst Paraibano Diagnost EMBRION, BR-58400506 Campina Grande, Paraiba - Brazil
[15] Univ Pernambuco, Fac Ciencias Med, BR-50100130 Recife, PE - Brazil
[16] Univ Pernambuco, Inst Ciencias Biol, BR-50100130 Recife, PE - Brazil
[17] Fundacao Oswaldo Cruz, Inst Fernandes Figueira, BR-22250020 Rio De Janeiro - Brazil
[18] Inst Evandro Chagas, BR-67030000 Ananindeua - Brazil
[19] Fac Med Jundiai, BR-13211383 Jundiai - Brazil
[20] Inst DOr Pesquisa & Ensino, BR-22281100 Rio De Janeiro - Brazil
[21] Univ Fed Bahia, Inst Saude Colet, BR-40110040 Salvador, BA - Brazil
[22] Univ Fed Rio Grande do Sul, BR-91501970 Porto Alegre, RS - Brazil
[23] Univ Fed Maranhao, Dept Saude Publ, BR-65020070 Sao Luis, Maranhao - Brazil
[24] Ctr Pesquisas Goncalo Moniz, BR-40296710 Salvador, BA - Brazil
[25] Secretaria Saude Estado Maranhao, Ctr Referencia Neurodesenvolvimento, Assistencia & Reabilitacao Criancas, BR-65076820 Sao Luis, Maranhao - Brazil
[26] Univ Fed Goias, Dept Saude Colet, BR-74605050 Goiania, Go - Brazil
[27] Univ Fed Pernambuco, Dept Med Trop, BR-50670901 Recife, PE - Brazil
Total Affiliations: 27
Document type: Journal article
Source: Viruses-Basel; v. 13, n. 4 APR 2021.
Web of Science Citations: 0
Abstract

Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions. (AU)

FAPESP's process: 15/12295-0 - Diagnostic of Brazilian and emergent arboviruses in patients and mosquitoes from two distinct regions in Brazil
Grantee:Ana Carolina Bernardes Terzian
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 17/21688-1 - Retrospective cohort of pregnant exposed to the Zika virus in São José do Rio Preto in 2016
Grantee:Marcos Tayar Augusto
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/05115-9 - Innate and adaptive immune response genes in the Zika virus infection
Grantee:Luiz Carlos de Mattos
Support Opportunities: Regular Research Grants
FAPESP's process: 16/08578-0 - Vertical infection by the virus Zika and its impact on the mother-child area
Grantee:Saulo Duarte Passos
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/15021-1 - Clinical-epidemiological study of a cohort of Zika infected pregnant women in São José do Rio Preto, SP
Grantee:Maurício Lacerda Nogueira
Support Opportunities: Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)
FAPESP's process: 13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018
Grantee:Maurício Lacerda Nogueira
Support Opportunities: Research Projects - Thematic Grants