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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Enzymatic removal of inhibitory compounds from lignocellulosic hydrolysates for biomass to bioproducts applications

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Author(s):
Tramontina, Robson [1, 2] ; Brenelli, Livia Beatriz [3] ; Sodre, Victoria [4, 5] ; Franco Cairo, Joao Paulo [4] ; Travalia, Beatriz Medeiros [2] ; Egawa, Viviane Yoshimi [6] ; Goldbeck, Rosana [2] ; Squina, Fabio Marcio [4]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas UNICAMP, Programa Posgrad Biociencias & Tecnol Prod Bioati, Campinas, SP - Brazil
[2] State Univ Campinas UNICAMP, Sch Food Engn, Campinas, SP - Brazil
[3] State Univ Campinas UNICAMP, Interdisciplinary Ctr Energy Planning NIPE, Campinas, SP - Brazil
[4] Univ Sorocaba UNISO, Programa Proc Tecnol & Ambientais, Sorocaba, SP - Brazil
[5] Univ Estadual Campinas UNICAMP, Programa Posgrad Biol Func & Mol BFM, Campinas, SP - Brazil
[6] Sao Paulo State Univ UNESP, Sch Agr, Botucatu, SP - Brazil
Total Affiliations: 6
Document type: Review article
Source: WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY; v. 36, n. 11 OCT 1 2020.
Web of Science Citations: 3
Abstract

The physicochemical pretreatment is an important step to reduce biomass recalcitrance and facilitate further processing of plant lignocellulose into bioproducts. This process results in soluble and insoluble biomass fractions, and both may contain by-products that inhibit enzymatic biocatalysts and microbial fermentation. These fermentation inhibitory compounds (ICs) are produced during the degradation of lignin and sugars, resulting in phenolic and furanic compounds, and carboxylic acids. Therefore, detoxification steps may be required to improve lignocellulose conversion by microoganisms. Several physical and chemical methods, such as neutralization, use of activated charcoal and organic solvents, have been developed and recommended for removal of ICs. However, biological processes, especially enzyme-based, have been shown to efficiently remove ICs with the advantage of minimizing environmental issues since they are biogenic catalysts and used in low quantities. This review focuses on describing several enzymatic approaches to promote detoxification of lignocellulosic hydrolysates and improve the performance of microbial fermentation for the generation of bioproducts. Novel strategies using classical carbohydrate active enzymes (CAZymes), such as laccases (AA1) and peroxidases (AA2), as well as more advanced strategies using prooxidant, antioxidant and detoxification enzymes (dubbed as PADs), i.e. superoxide dismutases, are discussed as perspectives in the field. (AU)

FAPESP's process: 18/18101-1 - Development of the CRISPR/Cas9 system in Rhodococcus jostii RHA1 for production of high-value chemicals from lignin streams
Grantee:Victoria Ramos Sodré de Castro
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/07926-4 - Novel integrative strategies through the aldoketo reductase from the termite Coptotermes gestroi for detoxification, saccharification and fermentation of lignocellulose aiming bioethanol production
Grantee:Robson Tramontina
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/50590-4 - Lignin valorization in cellulosic ethanol plants: biocatalytic conversion via ferulic acid to high value chemicals
Grantee:Fábio Márcio Squina
Support type: Program for Research on Bioenergy (BIOEN) - Thematic Grants
FAPESP's process: 20/03051-9 - Bioprocesses intensification, expansion of chemical products production and lignocellulose processing
Grantee:Viviane Yoshimi Egawa
Support type: Scholarships in Brazil - Technical Training Program - Technical Training
FAPESP's process: 17/15477-8 - Development of a low severity pretreatment process for the production of sugarcane straw oligosaccharides
Grantee:Lívia Beatriz Brenelli de Paiva
Support type: Scholarships in Brazil - Post-Doctorate