Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Photobiomodulation inhibits inflammation in the temporomandibular joint of rats

Full text
Author(s):
Pereira, Eliana de Souza Bastos Mazuqueli [1] ; Basting, Rosanna Tarkany [1] ; Abdalla, Henrique Ballassini [1] ; Garcez, Aguinaldo Silva [1] ; Napimoga, Marcelo Henrique [1] ; Clemente-Napimoga, Juliana Trindade [1]
Total Authors: 6
Affiliation:
[1] Sao Leopoldo Mandic Inst & Res Ctr, Lab Neuroimmune Interface Pain Res, Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY; v. 222, SEP 2021.
Web of Science Citations: 0
Abstract

Photobiomodulation (PBM) has been applied as a non-invasive technique for treating temporomandibular joint symptoms, especially on painful condition's relief, however the anti-inflammatory mechanism underlying the effect of PBM remains uncertain. This study aims to evaluate the mechanisms of action of PBM (808 nm) in a carrageenan-induced inflammation on temporomandibular joint (TMJ) of rats. In this study male Wistar rats were pre-treated with irradiation of a low-power diode laser for 15 s on TMJ (infra-red 808 nm, 100 mW, 50 J/ cm2 and 1.5 J) 15 min prior an injection in the temporomandibular joint of carrageenan (100 mu g/TMJ). 1 h after the TMJ treatments, the rats were terminally anesthetized for joint cavity wash and periarticular tissues collect. Samples analysis demonstrated that PBM inhibit leukocytes chemotaxis in the TMJ and significantly reduces amounts of TNF-alpha, IL-1I3 and CINC-1. In addition, Western blotting analysis demonstrated that PBM significantly decreased the protein levels of P2X3 and P2X7 receptors in the periarticular tissues. On the other hand, PBM was able to increase protein level of IL-10 (anti-inflammatory cytokine). In summary, it is possible to suggest that PBM inhibit inflammatory chemotaxis, modulation the balance of the pro- and anti-inflammatory characteristics of inflammatory cells. (AU)

FAPESP's process: 17/22334-9 - Use of drug delivery systems for the development and application of anti-inflammatory agents with potential immunomodulatory and neuroprotective effects
Grantee:Marcelo Henrique Napimoga
Support Opportunities: Research Projects - Thematic Grants