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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

sensitive electrochemical detection of metronidazole in synthetic serum and urine samples using low-cost screen-printed electrodes modified with reduced graphene oxide and C6

Full text
Author(s):
Materon, Elsa Maria [1, 2] ; Wong, Ademar [2] ; Freitas, Tayane Aguiar [2] ; Faria, Ronaldo Censi [2] ; Oliveira Jr, Osvaldo N.
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13560970 Sao Carlos - Brazil
[2] Univ Fed Sao Carlos, Dept Chem, BR-13560970 Sao Carlos - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF PHARMACEUTICAL ANALYSIS; v. 11, n. 5, p. 646-652, OCT 2021.
Web of Science Citations: 4
Abstract

Monitoring the concentration of antibiotics in body fluids is essential to optimizing the therapy and minimizing the risk of bacteria resistance, which can be made with electrochemical sensors tailored with appropriate materials. In this paper, we report on sensors made with screen-printed electrodes (SPE) coated with fullerene (C60), reduced graphene oxide (rGO) and Nafion (NF) (C60-rGO-NF/SPE) to determine the antibiotic metronidazole (MTZ). Under optimized conditions, the C60-rGO-NF/SPE sensor exhibited a linear response in square wave voltammetry for MTZ concentrations from 2.5 x 10-7 to 34 x 10-6 mol/L, with a detection limit of 2.1 x 10-7 mol/L. This sensor was also capable of detecting MTZ in serum and urine, with recovery between 94% and 100%, which are similar to those of the standard chromatographic method (HPLC-UV). Because the C60-rGO-NF/SPE sensor is amenable to mass production and allows for MTZ determination with simple principles of detection, it fulfills the requirements of therapeutic drug monitoring programs. (c) 2021 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). (AU)

FAPESP's process: 17/24053-7 - Development of simple electrochemical methods for the detection of biomarkers for the diagnosis of diseases
Grantee:Ronaldo Censi Faria
Support Opportunities: Regular Research Grants
FAPESP's process: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis
Grantee:Osvaldo Novais de Oliveira Junior
Support Opportunities: Research Projects - Thematic Grants