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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Detection of IncN-pST15 one-health plasmid harbouring bla(KPC-2) in a hypermucoviscous Klebsiella pneumoniae CG258 isolated from an infected dog, Brazil

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Author(s):
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Sellera, Fabio P. [1, 2] ; Fuga, Bruna [3, 4, 2] ; Fontana, Herrison [2] ; Esposito, Fernanda [3, 2] ; Cardoso, Brenda [3, 4] ; Konno, Sibele [5] ; Berl, Carla [5] ; Cappellanes, Mariana H. [5] ; Cortez, Marcia [5] ; Ikeda, Marcelo [5] ; de Souza, Cesar M. [1] ; Cerdeira, Louise [6] ; Lincopan, Nilton [3, 4, 2]
Total Authors: 13
Affiliation:
[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Internal Med, Sao Paulo - Brazil
[2] One Hlth Brazilian Resistance Project OneBR, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Pharm, Dept Clin Anal, Sao Paulo - Brazil
[5] PetCare Vet Hosp, Sao Paulo - Brazil
[6] Monash Univ, Dept Infect Dis, Cent Clin Sch, Clayton, Vic - Australia
Total Affiliations: 6
Document type: Journal article
Source: TRANSBOUNDARY AND EMERGING DISEASES; v. 68, n. 6, p. 3083-3088, NOV 2021.
Web of Science Citations: 3
Abstract

The emergence and rapid spread of carbapenemase-producing Enterobacterales represents a serious public health concern. Critically, these global priority bacteria have begun to be reported in companion animals, implying a potential risk of cross-transmission between humans and pets. Using long-read (MinION) and short-read (Illumina) sequencing technologies, we have identified and characterized a hypermucoviscous KPC-2-producing Klebsiella pneumoniae strain belonging to the high-risk international clone ST11/CG258, in a dog with urinary tract infection. Strikingly, the bla(KPC-2) gene was carried by a 54-kb IncN plasmid assignated to ST15, which shared 99.8 and 96.8% pairwise identity with IncN-pST15 plasmids from human and environmental K. pneumoniae strains, respectively; all come from an area with high endemicity of KPC-2. Our findings suggest that IncN-pST15 plasmids conferring carbapenem resistance can play as important a role as clonal transmission of K. pneumoniae, representing another major challenge for One Health. (AU)

FAPESP's process: 16/08593-9 - Pan-Resistome of beta-lactamase (KPC-2, CTX-M-8, CTX-M-15)-producing Klebsiella pneumoniae and Escherichia coli isolates endemic in Brazil
Grantee:Nilton Erbet Lincopan Huenuman
Support Opportunities: Regular Research Grants